Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients

Ignazio Cirillo, Catherine Klersy, Gian Luigi Marseglia, Andrea Vizzaccaro, Eugenio Pallestrini, Mariangela Tosca, Giorgio Ciprandi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: The small airways may play an important role in the clinical manifestations of asthma. Forced expiratory flow between 25% and 75% (FEF 25%-75%) has been proposed as an approximate measure of the caliber of distal airways. Bronchial hyperreactivity (BHR) is a feature of asthma. Objective: To evaluate the possible role of FEF25%-75% as a predictor of BHR in allergic patients with asthma and rhinitis. Methods: A total of 726 patients (mean ± SD age, 24.7 ± 6.3 years) were evaluated. Spirometry and methacholine bronchial challenge were evaluated in all the participants. Results: A difference between forced expiratory volume in 1 second and FEF25%_75% greater than 20 or a ratio between these variables greater than 1.24 discriminates between patients with no response to a mild response to methacholine vs patients with a moderate-to-severe response with high sensitivity (P <.001). Conclusion: This study highlights the possible role of FEF25%-75% in predicting BHR in allergic individuals with airway disorders.

Original languageEnglish
Pages (from-to)692-700
Number of pages9
JournalAnnals of Allergy, Asthma and Immunology
Volume96
Issue number5
Publication statusPublished - May 2006

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Bronchial Hyperreactivity
Asthma
Methacholine Chloride
Spirometry
Forced Expiratory Volume
Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

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Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients. / Cirillo, Ignazio; Klersy, Catherine; Marseglia, Gian Luigi; Vizzaccaro, Andrea; Pallestrini, Eugenio; Tosca, Mariangela; Ciprandi, Giorgio.

In: Annals of Allergy, Asthma and Immunology, Vol. 96, No. 5, 05.2006, p. 692-700.

Research output: Contribution to journalArticle

Cirillo, Ignazio ; Klersy, Catherine ; Marseglia, Gian Luigi ; Vizzaccaro, Andrea ; Pallestrini, Eugenio ; Tosca, Mariangela ; Ciprandi, Giorgio. / Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients. In: Annals of Allergy, Asthma and Immunology. 2006 ; Vol. 96, No. 5. pp. 692-700.
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