Role of FHIT in human cancer

Carlo M. Croce, Gabriella Sozzi, Kay Huebner

Research output: Contribution to journalArticlepeer-review


Through investigation of hemizygous and homozygous deletions in common human cancers, including lung cancer, we have cloned and characterized a gene at chromosome region 3p14.2, FHff, that is inactivated in epithelial tumors, particularly in tumors resulting from exposure to environmental carcinogens. In some tumors, particularly those associated with environmental carcinogens, alterations in the FHIT gene occur quite early in the development of cancer. In other cancers, Fhit inactivation seems to be a later event, possibly associated with progression to more aggressive neoplasias. Thus, detection of Fhit expression by immunohistochemistry in premalignant and malignant tissues may provide important diagnostic and prognostic information.

Original languageEnglish
Pages (from-to)1618-1624
Number of pages7
JournalJournal of Clinical Oncology
Issue number5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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