Ruolo degli alimenti nella sindrome orticaria-angioedema

Translated title of the contribution: Role of foodstuffs in angioedema urticaria syndrome

P. D. Pigatto, P. Persichini, L. Arancio

Research output: Contribution to journalArticle

Abstract

When asked about the possible causes of urticaria, most patients indicate dietary allergens, whereas the results of population studies have demonstrated a much lower prevalence. The pathogenetic mechanisms underlying the majority of reactions to food are still only partially understood. Milk, eggs, fish and soya are the most frequent culprits in children, whereas peanuts, walnuts, hazel nuts, cereals, fish, crustaceans, eggs and fresh fruit are the most common causes. Other foods act by means of an extra-immunological mechanism and, for example, may have direct lytic effects on mast cells. The clinical pictures of the dietary form are no different from those observed in other forms of urticaria. The most frequent (and often the only) symptom is urticaria/angioedema, whereas edema of the glottis seems to be the most frequent severe adverse reaction to foods. Anaphylaxis is the most feared consequence of dietary allergy and, in some cases, may be triggered by even minimal amounts of food. Diagnosis is based on anamnesis, skin tests (including those using fresh foods), specific serum IgE measurements, elimination diets, and tests of oral food exposure under various conditions. In addition to preventive measures, treatment includes symptomatic therapies ranging from anti-histamines and steroids for general purposes, to adrenaline for emergency cases. The most likely therapeutic hypotheses for the near future range from the infusion of anti-IgE monoclonal antibody to the use of vaccines in which the allergen is conjugated to specific segments of DNA that could stably modify Th2 responses to the allergen itself. Finally, genetic studies are currently under way with the aim of creating genetically modified foods devoid of allergenic proteins.

Original languageItalian
Pages (from-to)455-463
Number of pages9
JournalGiornale Italiano di Dermatologia e Venereologia
Volume139
Issue number5
Publication statusPublished - 2004

Fingerprint

Angioedema
Urticaria
Food
Allergens
Eggs
Fishes
Genetically Modified Food
Juglans
Glottis
Nuts
Anaphylaxis
Skin Tests
Mast Cells
Immunoglobulin E
Histamine
Epinephrine
Fruit
Edema
Hypersensitivity
Milk

ASJC Scopus subject areas

  • Dermatology

Cite this

Ruolo degli alimenti nella sindrome orticaria-angioedema. / Pigatto, P. D.; Persichini, P.; Arancio, L.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 139, No. 5, 2004, p. 455-463.

Research output: Contribution to journalArticle

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