Role of G-CSF GM-CSF in the management of infections in preterm newborns: An update

Research output: Contribution to journalArticle

Abstract

Neutropenia (definable as an absolute granulocyte count <1,000/μL in neonates) is a relatively frequent condition in small for gestational age and/or low birth weight neonates. Colony stimulating factors (CSF), namely granulocyte- (G-CSF) and granulocyte-macrophage- (GM-CSF) CSF, have been proposed for prophylaxis and therapy of severe infections in this condition. Available data do not support the use of these substances for prophylaxis of infections in the presence of neutropenia. On the contrary, there might be space for their use, mainly for G-CSF, in case of severe infectious complications in severely neutropenic neonates (absolute polymorphonuclear neutrophil count <500/μL) and/or in the presence of specific hematological diseases causing neutropenia.

Original languageEnglish
Pages (from-to)S15-S17
JournalEarly Human Development
Volume90
DOIs
Publication statusPublished - 2014

Fingerprint

Colony-Stimulating Factors
Neutropenia
Newborn Infant
Infection
Hematologic Diseases
Low Birth Weight Infant
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Granulocytes
Gestational Age
Neutrophils
Therapeutics

Keywords

  • G-CSF
  • GM-CSF
  • Growth factor
  • Neonate
  • Neutropenia
  • Sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

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title = "Role of G-CSF GM-CSF in the management of infections in preterm newborns: An update",
abstract = "Neutropenia (definable as an absolute granulocyte count <1,000/μL in neonates) is a relatively frequent condition in small for gestational age and/or low birth weight neonates. Colony stimulating factors (CSF), namely granulocyte- (G-CSF) and granulocyte-macrophage- (GM-CSF) CSF, have been proposed for prophylaxis and therapy of severe infections in this condition. Available data do not support the use of these substances for prophylaxis of infections in the presence of neutropenia. On the contrary, there might be space for their use, mainly for G-CSF, in case of severe infectious complications in severely neutropenic neonates (absolute polymorphonuclear neutrophil count <500/μL) and/or in the presence of specific hematological diseases causing neutropenia.",
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AU - Castagnola, Elio

AU - Dufour, Carlo

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AB - Neutropenia (definable as an absolute granulocyte count <1,000/μL in neonates) is a relatively frequent condition in small for gestational age and/or low birth weight neonates. Colony stimulating factors (CSF), namely granulocyte- (G-CSF) and granulocyte-macrophage- (GM-CSF) CSF, have been proposed for prophylaxis and therapy of severe infections in this condition. Available data do not support the use of these substances for prophylaxis of infections in the presence of neutropenia. On the contrary, there might be space for their use, mainly for G-CSF, in case of severe infectious complications in severely neutropenic neonates (absolute polymorphonuclear neutrophil count <500/μL) and/or in the presence of specific hematological diseases causing neutropenia.

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