Ruolo della radiochirurgia stereotassica mediante Gamma Knife nel trattamento degli adenomi ipofisari

Translated title of the contribution: Role of Gamma knife radiosurgery in the management of pituitary adenomas

P. Picozzi, P. Mortini, M. Losa, A. Franzin, L. Attuati, M. A. Valle, L. Gioia, A. Vimercati, C. Serra, P. Ribotto, A. Del Vecchio, M. Giovanelli

Research output: Contribution to journalArticlepeer-review


Stereotactic radiosurgery has become a valuable tool in adjuvant therapy of pituitary adenomas due to its high effectiveness and its low incidence of side effects. We present a retrospective evaluation of Gamma Knife treatment in 248 patients affected by pituitary adenomas (109 non-secreting. Secreting adenomas: 12 PRL, 50 ACTH, 77 GH). All patients underwent clinical-instrumental follow up for at least 6 months. Therapy response criteria were: tumoural mass control and endocrine remission. Results: tumoural mass control rate was achieved in 243/248 patients (non-responders: 3 non-secreting, 1 ACTH-secreting, 1 PRL-secreting). Endocrine remission rate: GH-secreting 60.6%, PRL-secreting 50%, ACTH-secreting 42%). Side effects: hormonal deficit rate 5% (13/248: 4 hypothyroidism, 7 hypogonadism, 2 hyposurrenalism). Conclusion: radiosurgical treatment with gamma knife is a safe and effective adjuvant therapeutic option in the management of pitutary adenomas.

Translated title of the contributionRole of Gamma knife radiosurgery in the management of pituitary adenomas
Original languageItalian
Pages (from-to)105-110
Number of pages6
JournalRivista Medica
Issue number1
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Medicine(all)


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