Stereotactic radiosurgery has become a valuable tool in adjuvant therapy of pituitary adenomas due to its high effectiveness and its low incidence of side effects. We present a retrospective evaluation of Gamma Knife treatment in 248 patients affected by pituitary adenomas (109 non-secreting. Secreting adenomas: 12 PRL, 50 ACTH, 77 GH). All patients underwent clinical-instrumental follow up for at least 6 months. Therapy response criteria were: tumoural mass control and endocrine remission. Results: tumoural mass control rate was achieved in 243/248 patients (non-responders: 3 non-secreting, 1 ACTH-secreting, 1 PRL-secreting). Endocrine remission rate: GH-secreting 60.6%, PRL-secreting 50%, ACTH-secreting 42%). Side effects: hormonal deficit rate 5% (13/248: 4 hypothyroidism, 7 hypogonadism, 2 hyposurrenalism). Conclusion: radiosurgical treatment with gamma knife is a safe and effective adjuvant therapeutic option in the management of pitutary adenomas.
|Translated title of the contribution||Role of Gamma knife radiosurgery in the management of pituitary adenomas|
|Number of pages||6|
|Publication status||Published - Mar 2007|
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