Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis

Michele De Palma, Luigi Naldini

Research output: Contribution to journalArticle

Abstract

Bone marrow-derived cells include haematopoietic cell lineages and the recently described endothelial progenitor cells (EPCs). It has been recently emphasised that these marrow-derived cells contribute to tumour angiogenesis, and different mechanisms have been proposed that account for this activity. Whereas haematopoietic cells may promote tumour angiogenesis through the release of proangiogenic factors or by creating permissive conditions in the tumour microenvironment that favour the growth of locally derived blood vessels ("paracrine" role), endothelial progenitors are thought to directly incorporate into nascent blood vessels as bona fide endothelial cells ("building block" role). The relative contribution of these distinct pathways to tumour angiogenesis is the subject of intense investigation and debate.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1766
Issue number1
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Hematopoietic cell
  • Proangiogenic cell
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Biophysics

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