Role of haemorheological factors in patients with retinal vein occlusion

Francesco Sofi, Lucia Mannini, Rossella Marcucci, Paola Bolli, Andrea Sodi, Barbara Giambene, Ugo Menchini, Gian Franco Gensini, Rosanna Abbate, Domenico Prisco

Research output: Contribution to journalArticlepeer-review


Retinal vein occlusion (RVO) is an important cause of permanent visual loss. Hyperviscosity, due to alterations of blood cells and plasma components, may play a role in the pathogenesis of RVO. Aim of this case-control study was to evaluate the possible association between haemorheology and RVO. In 180 RVO patients and in 180 healthy subjects comparable for age and gender we analysed the whole haemorheological profile: [whole blood viscosity (WBV), erythrocyte deformability index (DI), plasma viscosity (PLV), and fibrinogen]. WBV and PLV were measured using a rotational viscosimeter, whereas DI was measured by a microcomputer-assisted filtrometer. WBV at 0.512 sec-1 and 94.5 sec-1 shear rates as well as DI, but not PLV, were found to be significantly different in patients as compared to healthy subjects.At the logistic univariate analysis, a significant association between the highest tertiles of WBV at 94.5 sec-1 shear rate (OR:4.91,95%CI 2.95-8.17; p-1 shear rate (OR: 2.31,95%CI 1.42-3.77; p-1 shear rate (OR: 3.23, 95%CI 1.39-7.48; p=0.006),WBV at 94.5 sec-1 shear rate (OR: 6.74,95%CI 3.06-14.86; p

Original languageEnglish
Pages (from-to)1215-1219
Number of pages5
JournalThrombosis and Haemostasis
Issue number6
Publication statusPublished - Dec 2007


  • Blood viscosity
  • Haemodilution
  • Haemorheology
  • Retinal vein occlusion

ASJC Scopus subject areas

  • Hematology


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