TY - JOUR
T1 - Role of hepatic autoregulation in defense against hypoglycemia in humans
AU - Bolli, G.
AU - de Feo, P.
AU - Perriello, G.
AU - De Cosmo, S.
AU - Ventura, M.
AU - Campbell, P.
AU - Brunetti, P.
AU - Gerich, J. E.
PY - 1985
Y1 - 1985
N2 - To assess the role of hepatic autoregulation in defense against hypoglycemia, we compared the effects of complete blockade of glucose counterregulation with those of blockade of only neurohumoral counter regulation during moderate (~50 mg/dl) and severe (~30 mg/dl) hypoglycemia induced by physiologic hyperinsulinemia during subcutaneous infusion of insulin in normal volunteers. Compared with observations in control experiments, neurohumoral counterregulatory blockade (somatostatin, propranolol, phentolamine, and metyrapone) during which identical moderate hypoglycemia was achieved using the glucose clamp technique, resulted in suppressed glucose production (0.62±0.08 vs. 1.56±0.07 mg/kg per min at 12 h, P
AB - To assess the role of hepatic autoregulation in defense against hypoglycemia, we compared the effects of complete blockade of glucose counterregulation with those of blockade of only neurohumoral counter regulation during moderate (~50 mg/dl) and severe (~30 mg/dl) hypoglycemia induced by physiologic hyperinsulinemia during subcutaneous infusion of insulin in normal volunteers. Compared with observations in control experiments, neurohumoral counterregulatory blockade (somatostatin, propranolol, phentolamine, and metyrapone) during which identical moderate hypoglycemia was achieved using the glucose clamp technique, resulted in suppressed glucose production (0.62±0.08 vs. 1.56±0.07 mg/kg per min at 12 h, P
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M3 - Article
C2 - 2860128
AN - SCOPUS:0021869034
VL - 75
SP - 1623
EP - 1631
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 5
ER -