Role of hepatic autoregulation in defense against hypoglycemia in humans

G. Bolli, P. de Feo, G. Perriello, S. De Cosmo, M. Ventura, P. Campbell, P. Brunetti, J. E. Gerich

Research output: Contribution to journalArticlepeer-review


To assess the role of hepatic autoregulation in defense against hypoglycemia, we compared the effects of complete blockade of glucose counterregulation with those of blockade of only neurohumoral counter regulation during moderate (~50 mg/dl) and severe (~30 mg/dl) hypoglycemia induced by physiologic hyperinsulinemia during subcutaneous infusion of insulin in normal volunteers. Compared with observations in control experiments, neurohumoral counterregulatory blockade (somatostatin, propranolol, phentolamine, and metyrapone) during which identical moderate hypoglycemia was achieved using the glucose clamp technique, resulted in suppressed glucose production (0.62±0.08 vs. 1.56±0.07 mg/kg per min at 12 h, P

Original languageEnglish
Pages (from-to)1623-1631
Number of pages9
JournalJournal of Clinical Investigation
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Medicine(all)


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