Role of hepatitis B virus infection in the prognosis after hepatectomy for hepatocellular carcinoma in patients with cirrhosis: A western dual-center experience

Hypothesis: The role of hepatitis B virus (HBV) infection in determining the prognosis after hepatectomy for hepatocellular carcinoma (HCC) in patients with cirrhosis is controversial. Design: Retrospective study based on multicenter prospectively updated databases. Setting: Two tertiary referral centers specializing in hepatobiliary surgery. Patients: Two hundred four consecutive patients with cirrhosis undergoing hepatectomy for single nodules of HCC of 5 cm or smaller from January 1, 1997, through September 30, 2006. Interventions: Patients were divided into the following groups according to their preoperative viral status: HBV positive and hepatitisCvirus (HCV) negative (group 1); HBV negative and HCV positive (group 2); HBV negative and HCV negative (group 3); and HBV positive and HCV positive (group 4). Main Outcome Measures: A multivariate analysis was performed to determine factors associated with recurrence-free survival (RFS) among demographic, clinical, pathological, and surgical variables. Results: The 2 centers had comparable RFS and early and late recurrence rates. Five-year RFS was significantly higher in groups 2 and 3 compared with group 1 (38%, 34%, and 9%, respectively; P=.007 and P=.05). Factors independently associated with RFS were HBV infection (P=.009; odds ratio, 1.79; 95% confidence interval, 1.15-2.78) and poor tumor differentiation (P