Role of HER receptors family in development and differentiation

Patrizia Casalini, Marilena V. Iorio, Enrico Galmozzi, Sylvie Ménard

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Members of the epidermal growth factor receptor family of receptor tyrosine kinases play a critical role in both development and oncogenesis. The latter is suggested by the frequent overexpression of HER-2, EGFR, and HER-3 in some human carcinomas, primarily breast and squamous cancer. The biological activities of the EGFR family are exerted through various ligand-receptor and receptor-receptor interactions. One receptor that plays a central role in this signaling network is HER-2/Neu, which is considered the preferred heterodimerization partner for other members of the EGFR family. The role of these receptors and their ligands in development is discussed, with particular emphasis on their ability to mediate a variety of pathways and cellular responses, including proliferation, differentiation, and apoptosis.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalJournal of Cellular Physiology
Volume200
Issue number3
DOIs
Publication statusPublished - Sep 2004

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Ligands
Aptitude
Receptor Protein-Tyrosine Kinases
Bioactivity
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Carcinogenesis
Apoptosis
Breast Neoplasms
ErbB Receptors

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Casalini, P., Iorio, M. V., Galmozzi, E., & Ménard, S. (2004). Role of HER receptors family in development and differentiation. Journal of Cellular Physiology, 200(3), 343-350. https://doi.org/10.1002/jcp.20007

Role of HER receptors family in development and differentiation. / Casalini, Patrizia; Iorio, Marilena V.; Galmozzi, Enrico; Ménard, Sylvie.

In: Journal of Cellular Physiology, Vol. 200, No. 3, 09.2004, p. 343-350.

Research output: Contribution to journalArticle

Casalini, P, Iorio, MV, Galmozzi, E & Ménard, S 2004, 'Role of HER receptors family in development and differentiation', Journal of Cellular Physiology, vol. 200, no. 3, pp. 343-350. https://doi.org/10.1002/jcp.20007
Casalini, Patrizia ; Iorio, Marilena V. ; Galmozzi, Enrico ; Ménard, Sylvie. / Role of HER receptors family in development and differentiation. In: Journal of Cellular Physiology. 2004 ; Vol. 200, No. 3. pp. 343-350.
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