Il ruolo dell'acido ialuronico ad alto peso molecolare nell'atrofia vaginale in postmenopausa

Translated title of the contribution: Role of high molecular weight hyaluronic acid in postmenopausal vaginal discomfort

E. P. Grimaldi, S. Restaino, S. Inglese, L. Foltran, A. Sorz, G. Di Lorenzo, S. Guaschino

Research output: Contribution to journalArticle

Abstract

Aim. Aim of the present study was to quantify the intensity of vulvovaginal symptoms before and after treatment with high molecular weight hyaluronic acid (HA), to test the tolerability and safety of the product, to evaluate the effect on the quality of life and the compliance to the treatment. Methods. This was a double-blind randomized placebo-controlled study. In seven months we enrolled 36 post-menopausal women, equally distributed in placebo and active group. The evaluation was based on at least three atrophy-related signs and on the patient reported symptoms. After the written informed consent, the participants were instructed to apply the gel (drug or placebo) daily. Three days after the end of the treatment the patients received a final examination to evaluate the progress of symptoms, the presence of any adverse events and their correlation with the treatment. Results. Self-evaluation scales and investigator evaluation showed that the vaginal dryness was significantly reduced both in placebo and in the active group; however, high molecular weight HA was the only active treatment in reducing significantly itching and burning (P

Translated title of the contributionRole of high molecular weight hyaluronic acid in postmenopausal vaginal discomfort
Original languageItalian
Pages (from-to)321-329
Number of pages9
JournalMinerva Ginecologica
Volume64
Issue number4
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Grimaldi, E. P., Restaino, S., Inglese, S., Foltran, L., Sorz, A., Di Lorenzo, G., & Guaschino, S. (2012). Il ruolo dell'acido ialuronico ad alto peso molecolare nell'atrofia vaginale in postmenopausa. Minerva Ginecologica, 64(4), 321-329.