Role of IL-15 in immune-mediated and infectious diseases

Antonio Di Sabatino, Sandra A. Calarota, Francesca Vidali, Thomas T. MacDonald, Gino R. Corazza

Research output: Contribution to journalArticle

Abstract

IL-15 has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. However, IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Therefore, targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. On the other hand, in some infectious diseases, IL-15 production is compromised but IL-15 given exogenously can potentially enhance immune responses to pathogens. Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use.

Original languageEnglish
Pages (from-to)19-33
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Autoimmune diseases
  • IL-15
  • Immune system
  • Immune-therapeutic tool
  • Infectious diseases

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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