Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment

Maria Romano, Marina Sironi, Carlo Toniatti, Nadia Polentarutti, Paolo Fruscella, Pietro Ghezzi, Raffaella Faggioni, Walter Luini, Victor Van Hinsbergh, Silvano Sozzani, Federico Bussolino, Valeria Poli, Gennaro Ciliberto, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

IL-6(-/-) mice showed impaired leukocyte accumulation in subcutaneous air pouches. Defective leukocyte accumulation was not due to a reduced migratory capacity of IL-6(-/-) leukocytes and was associated with a reduced in situ production of chemokines. These observations led to a reexamination of the interaction of IL-6 with endothelial cells (EC). EC express only the gp130 signal transducing chain and not the subunit-specific IL-6R and are therefore unresponsive to IL-6. However, EC are responsive to a combination of IL-6 and soluble IL-6R as measured by the activation of STAT3, chemokine expression, and augmentation of ICAM-1. Activation by IL-6-IL-6R complexes was inhibited by an IL-6 receptor antagonist and potentiated by a superagonist. Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment.

Original languageEnglish
Pages (from-to)315-325
Number of pages11
JournalImmunity
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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