TY - JOUR
T1 - Role of immune-derived diffusible mediators in AIDS-associated neurological disorders
AU - Ensoli, Fabrizio
AU - Fiorelli, Valeria
AU - De Cristofaro, Maria
AU - Santini Muratori, Donatella
AU - Novi, Arianna
AU - Isgrò, Antonella
AU - Aiuti, Fernando
PY - 2000
Y1 - 2000
N2 - Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
AB - Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
KW - AIDS patients
KW - Neural cells
KW - Neurological disorders
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M3 - Article
C2 - 11059642
AN - SCOPUS:0034571678
VL - 48
SP - 259
EP - 266
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
SN - 0004-069X
IS - 4
ER -