Abstract
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 259-266 |
| Number of pages | 8 |
| Journal | Archivum Immunologiae et Therapiae Experimentalis |
| Volume | 48 |
| Issue number | 4 |
| Publication status | Published - 2000 |
Fingerprint
Keywords
- AIDS patients
- Neural cells
- Neurological disorders
ASJC Scopus subject areas
- Immunology
Cite this
Role of immune-derived diffusible mediators in AIDS-associated neurological disorders. / Ensoli, Fabrizio; Fiorelli, Valeria; De Cristofaro, Maria; Santini Muratori, Donatella; Novi, Arianna; Isgrò, Antonella; Aiuti, Fernando.
In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 48, No. 4, 2000, p. 259-266.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of immune-derived diffusible mediators in AIDS-associated neurological disorders
AU - Ensoli, Fabrizio
AU - Fiorelli, Valeria
AU - De Cristofaro, Maria
AU - Santini Muratori, Donatella
AU - Novi, Arianna
AU - Isgrò, Antonella
AU - Aiuti, Fernando
PY - 2000
Y1 - 2000
N2 - Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
AB - Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
KW - AIDS patients
KW - Neural cells
KW - Neurological disorders
UR - http://www.scopus.com/inward/record.url?scp=0034571678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034571678&partnerID=8YFLogxK
M3 - Article
C2 - 11059642
AN - SCOPUS:0034571678
VL - 48
SP - 259
EP - 266
JO - Archivum Immunologiae et Therapiae Experimentalis
JF - Archivum Immunologiae et Therapiae Experimentalis
SN - 0004-069X
IS - 4
ER -