Abstract
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 259-266 |
| Number of pages | 8 |
| Journal | Archivum Immunologiae et Therapiae Experimentalis |
| Volume | 48 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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Keywords
- AIDS patients
- Neural cells
- Neurological disorders
ASJC Scopus subject areas
- Immunology
Cite this
Ensoli, F., Fiorelli, V., De Cristofaro, M., Santini Muratori, D., Novi, A., Isgrò, A., & Aiuti, F. (2000). Role of immune-derived diffusible mediators in AIDS-associated neurological disorders. Archivum Immunologiae et Therapiae Experimentalis, 48(4), 259-266.