Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

Fabrizio Ensoli, Valeria Fiorelli, Maria De Cristofaro, Donatella Santini Muratori, Arianna Novi, Antonella Isgrò, Fernando Aiuti

Research output: Contribution to journalArticlepeer-review


Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.

Original languageEnglish
Pages (from-to)259-266
Number of pages8
JournalArchivum Immunologiae et Therapiae Experimentalis
Issue number4
Publication statusPublished - 2000


  • AIDS patients
  • Neural cells
  • Neurological disorders

ASJC Scopus subject areas

  • Immunology


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