Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

Fabrizio Ensoli; Valeria Fiorelli; Maria De Cristofaro; Donatella Santini Muratori; Arianna Novi; Antonella Isgrò; Fernando Aiuti

Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

Fabrizio Ensoli, Valeria Fiorelli, Maria De Cristofaro, Donatella Santini Muratori, Arianna Novi, Antonella Isgrò, Fernando Aiuti

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.

Original language	English
Pages (from-to)	259-266
Number of pages	8
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	48
Issue number	4
Publication status	Published - 2000

Keywords

AIDS patients
Neural cells
Neurological disorders

ASJC Scopus subject areas

Immunology

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Role of immune-derived diffusible mediators in AIDS-associated neurological disorders. / Ensoli, Fabrizio; Fiorelli, Valeria; De Cristofaro, Maria; Santini Muratori, Donatella; Novi, Arianna; Isgrò, Antonella; Aiuti, Fernando.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 48, No. 4, 2000, p. 259-266.

Research output: Contribution to journal › Article › peer-review

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AU - Isgrò, Antonella

AU - Aiuti, Fernando

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