TY - JOUR
T1 - Role of in vitro testing in food allergy
AU - Arasi, Stefania
AU - Barni, Simona
AU - Mastrorilli, Carla
AU - Comberiati, Pasquale
AU - Chiera, Fernanda
AU - Pelosi, Umberto
AU - Paravati, Francesco
AU - Caimmi, Davide
N1 - Publisher Copyright:
© 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2020/11
Y1 - 2020/11
N2 - Oral food challenges remain the gold standard for the diagnosis of food allergy. Nevertheless, the allergy workup is based on the presence of a clinical history, which is evocative of an immune-allergic reaction, and the first assessment is usually the performance of skin prick tests. Based on these results, allergists are used to evaluate the presence of serum-specific IgE, which are today the most commonly prescribed in vitro test for the evaluation of a possible food allergy. Other in vitro tests include the basophil activation test, that is becoming more and more employed by clinicians and not only by researchers, and the evaluation of serum IgG4, which is still an issue of debate in the allergy community. The present paper reviews the use of these in vitro tests for the diagnosis of food allergy.
AB - Oral food challenges remain the gold standard for the diagnosis of food allergy. Nevertheless, the allergy workup is based on the presence of a clinical history, which is evocative of an immune-allergic reaction, and the first assessment is usually the performance of skin prick tests. Based on these results, allergists are used to evaluate the presence of serum-specific IgE, which are today the most commonly prescribed in vitro test for the evaluation of a possible food allergy. Other in vitro tests include the basophil activation test, that is becoming more and more employed by clinicians and not only by researchers, and the evaluation of serum IgG4, which is still an issue of debate in the allergy community. The present paper reviews the use of these in vitro tests for the diagnosis of food allergy.
KW - basophil activation test
KW - component resolved diagnostics
KW - food allergy
KW - IgE-mediated
KW - IgG
KW - specific IgE
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U2 - 10.1111/pai.13342
DO - 10.1111/pai.13342
M3 - Article
C2 - 33236420
AN - SCOPUS:85096446260
VL - 31
SP - 36
EP - 38
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
SN - 0905-6157
IS - S26
ER -