Abstract
Summary: The effect of increased cholinergic activity on reperfusion induced ventricular arrhythmias was studied in alpha chloralose anaesthetised dogs by administering neostigmine during a 25 min occlusion of the anterior left descending coronary artery. The dogs were divided into five groups, each of 10 animals: the control group received only saline solution; group 1 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion (that is, 5 min before reperfusion); group 2 atropine 0.4 mg·kg-1 iv at 10 min of coronary occlusion and neostigmine 0.03 mg·kg-1 iv at 20 min; and group 3 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion and at the same time underwent atrial pacing at the same rate as that of the sinus node just before neostigmine administration. In group 4 heart rate was slowed (junctional rhythm) by destroying the sinus node at 20 min of coronary occlusion. The results obtained showed that ventricular tachycardia and fibrillation, which occur at the beginning of reperfusion, were significantly less frequent in group 1 (p
| Original language | English |
|---|---|
| Pages (from-to) | 279-285 |
| Number of pages | 7 |
| Journal | Cardiovascular Research |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1987 |
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Keywords
- Heart rate
- Neostigmine
- Reperfusion arrhythmias
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Role of increased cholinergic activity in reperfusion induced ventricular arrhythmias. / Ferrara, Nicola; Bonaduce, Domenico; Abete, Pasquale; Leosco, Dario; Longobardi, Giancarlo; Canonico, Vincenzo; Rengo, Franco.
In: Cardiovascular Research, Vol. 21, No. 4, 04.1987, p. 279-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of increased cholinergic activity in reperfusion induced ventricular arrhythmias
AU - Ferrara, Nicola
AU - Bonaduce, Domenico
AU - Abete, Pasquale
AU - Leosco, Dario
AU - Longobardi, Giancarlo
AU - Canonico, Vincenzo
AU - Rengo, Franco
PY - 1987/4
Y1 - 1987/4
N2 - Summary: The effect of increased cholinergic activity on reperfusion induced ventricular arrhythmias was studied in alpha chloralose anaesthetised dogs by administering neostigmine during a 25 min occlusion of the anterior left descending coronary artery. The dogs were divided into five groups, each of 10 animals: the control group received only saline solution; group 1 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion (that is, 5 min before reperfusion); group 2 atropine 0.4 mg·kg-1 iv at 10 min of coronary occlusion and neostigmine 0.03 mg·kg-1 iv at 20 min; and group 3 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion and at the same time underwent atrial pacing at the same rate as that of the sinus node just before neostigmine administration. In group 4 heart rate was slowed (junctional rhythm) by destroying the sinus node at 20 min of coronary occlusion. The results obtained showed that ventricular tachycardia and fibrillation, which occur at the beginning of reperfusion, were significantly less frequent in group 1 (p
AB - Summary: The effect of increased cholinergic activity on reperfusion induced ventricular arrhythmias was studied in alpha chloralose anaesthetised dogs by administering neostigmine during a 25 min occlusion of the anterior left descending coronary artery. The dogs were divided into five groups, each of 10 animals: the control group received only saline solution; group 1 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion (that is, 5 min before reperfusion); group 2 atropine 0.4 mg·kg-1 iv at 10 min of coronary occlusion and neostigmine 0.03 mg·kg-1 iv at 20 min; and group 3 neostigmine 0.03 mg·kg-1 iv at 20 min of coronary occlusion and at the same time underwent atrial pacing at the same rate as that of the sinus node just before neostigmine administration. In group 4 heart rate was slowed (junctional rhythm) by destroying the sinus node at 20 min of coronary occlusion. The results obtained showed that ventricular tachycardia and fibrillation, which occur at the beginning of reperfusion, were significantly less frequent in group 1 (p
KW - Heart rate
KW - Neostigmine
KW - Reperfusion arrhythmias
UR - http://www.scopus.com/inward/record.url?scp=0023128282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023128282&partnerID=8YFLogxK
U2 - 10.1093/cvrese/21.4.279
DO - 10.1093/cvrese/21.4.279
M3 - Article
C2 - 3652095
VL - 21
SP - 279
EP - 285
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 4
ER -