Role of Infiltrating Microglia/Macrophages in Glioma

Myriam Catalano, Giuseppina D'Alessandro, Flavia Trettel, Cristina Limatola

Research output: Contribution to journalReview articlepeer-review


In this chapter we describe the state of the art knowledge of the role played by myeloid cells in promoting and supporting the growth and the invasive properties of a deadly brain tumor, glioblastoma. We provide a review of the works describing the intercellular communication among glioma and associated microglia/macrophage cells (GAMs) using in vitro cellular models derived from mice, rats and human patients and in vivo animal models using syngeneic or xenogeneic experimental systems. Special emphasis will be given to 1) the timing alteration of brain microenvironment under the influence of glioma, 2) the bidirectional communication among tumor and GAMs, 3) possible approaches to interfere with or to guide these interactions, with the aim to identify molecular and cellular targets which could revert or delay the vicious cycle that favors tumor biology.

Original languageEnglish
Pages (from-to)281-298
Number of pages18
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 2020


  • Animals
  • Brain Neoplasms/pathology
  • Glioma/pathology
  • Humans
  • Macrophages/pathology
  • Microglia/pathology
  • Tumor Microenvironment


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