Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system

Beatrice Macchi, Francesca Marino-Merlo, Ugo Nocentini, Valerio Pisani, Salvatore Cuzzocrea, Sandro Grelli, Antonio Mastino

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a complex, multifactorial disease associated with damage to the axonal myelin sheaths and neuronal degeneration. The pathognomonic event in MS is oligodendrocyte loss accompanied by axonal damage, blood-brain barrier leakage, inflammation and infiltration of immune cells. The etiopathogenesis of MS is far from being elucidated. However, increasing evidence suggests that the inflammatory and apoptotic responses, occurring in patients either at the peripheral level or the central nervous system (CNS), can play a role. In this review, we give a comprehensive picture of general aspects of inflammation and apoptosis in MS, with special emphasis on the until now not well highlighted possible links between phenomena relevant to these aspects occurring in either the periphery or in the CNS during MS.

Original languageEnglish
Article number476196
Pages (from-to)80-87
Number of pages8
JournalJournal of Neuroimmunology
Volume287
DOIs
Publication statusPublished - Oct 15 2015

Keywords

  • Apoptosis
  • Inflammation
  • Multiple sclerosis
  • Targeted therapy

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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