Role of inflammation in obesity-related breast cancer

Research output: Contribution to journalReview article

Abstract

Chronic inflammation associated with obesity is now recognized to be an important condition in promoting carcinogenesis and progression in breast cancer patients, mostly in postmenopausal women with tumors expressing estrogen and progesterone receptors. In obese patients, altered levels of several inflammatory mediators regulating aromatase and estrogen expression are one of the mechanisms responsible of increase breast cancer risk. Growing attention has also been paid to the local adipose inflammation and the role played by macrophages as determinants of breast cancer risk recurrence and prognosis. The inflammation-obesity axis offers different molecular signaling pathways for therapeutic interventions and potential pharmacological targets. The increasing rate of obesity worldwide associated with the recent findings linking inflammation and breast cancer urge further investigation.

Original languageEnglish
Pages (from-to)114-122
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume31
DOIs
Publication statusPublished - Dec 1 2016

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Obesity
Breast Neoplasms
Inflammation
Aromatase
Progesterone Receptors
Estrogen Receptors
Estrogens
Carcinogenesis
Macrophages
Pharmacology
Recurrence
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Role of inflammation in obesity-related breast cancer. / Crespi, Elisa; Bottai, Giulia; Santarpia, Libero.

In: Current Opinion in Pharmacology, Vol. 31, 01.12.2016, p. 114-122.

Research output: Contribution to journalReview article

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