Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco

Translated title of the contribution: Role of inflammatory mediators in congestive heart failure pathogenesis

F. V. Boglioni, M. Metra, M. Locati, S. Nodari, L. Bontempi, M. Garbellini, A. Doni, G. Peri, A. Mantovani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A number of factors are involved in congestive heart failure pathogenesis. Among these, inflammatory mediators could have a crucial role. Patients with congestive heart failure show increased plasma levels of "proinflammatory cytokines", in particular tumor necrosis factor-α and interleukin-6. Clinical and experimental models have demonstrated that these cytokines induce left ventricular dysfunction, pulmonary edema, ventricular remodeling, skeletal muscle abnormalities, myocyte apoptosis and endothelial dysfunction, suggesting the possibility that increased plasma concentration of cytokines could not be just an epiphenomenon, but an effective pathogenetic mechanism of disease progression. Additional inflammatory proteins involved in the acute phase response could play a part in the pathogenesis of heart failure. Pentraxin 3 is a prototypical long pentraxin, structurally related, although with different functions, to C-reactive protein, is produced by immune system cells, fibroblasts and particularly by cardiac endothelial cells and myocytes, as demonstrated in murine and human models. Its synthesis is rapidly induced after exposition to bacterial lipopolysaccharide and proinflammatory cytokines, as interleukin-1β and tumor necrosis factor-α. In heart diseases, pentraxin 3 could be involved in the acute local inflammatory response to myocardial injury (e.g. necrosis) and in heart failure pathogenetic mechanisms, but its exact role is not yet settled. Defining the specific part played by these molecules in the pathogenesis of heart failure could lead to new therapeutic approaches in the treatment of cardiac insufficiency.

Original languageItalian
Pages (from-to)628-633
Number of pages6
JournalItalian Heart Journal Supplement
Volume2
Issue number6
Publication statusPublished - 2001

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Heart Failure
Cytokines
Muscle Cells
Tumor Necrosis Factor-alpha
Acute-Phase Reaction
Ventricular Remodeling
Left Ventricular Dysfunction
Pulmonary Edema
Interleukin-1
C-Reactive Protein
Lipopolysaccharides
Disease Progression
Immune System
Heart Diseases
Interleukin-6
Skeletal Muscle
Theoretical Models
Necrosis
Endothelial Cells
Fibroblasts

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Boglioni, F. V., Metra, M., Locati, M., Nodari, S., Bontempi, L., Garbellini, M., ... Mantovani, A. (2001). Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco. Italian Heart Journal Supplement, 2(6), 628-633.

Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco. / Boglioni, F. V.; Metra, M.; Locati, M.; Nodari, S.; Bontempi, L.; Garbellini, M.; Doni, A.; Peri, G.; Mantovani, A.

In: Italian Heart Journal Supplement, Vol. 2, No. 6, 2001, p. 628-633.

Research output: Contribution to journalArticle

Boglioni, FV, Metra, M, Locati, M, Nodari, S, Bontempi, L, Garbellini, M, Doni, A, Peri, G & Mantovani, A 2001, 'Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco', Italian Heart Journal Supplement, vol. 2, no. 6, pp. 628-633.
Boglioni FV, Metra M, Locati M, Nodari S, Bontempi L, Garbellini M et al. Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco. Italian Heart Journal Supplement. 2001;2(6):628-633.
Boglioni, F. V. ; Metra, M. ; Locati, M. ; Nodari, S. ; Bontempi, L. ; Garbellini, M. ; Doni, A. ; Peri, G. ; Mantovani, A. / Ruolo dei mediatori dell'infiammazione nella patogenesi dello scompenso cardiaco. In: Italian Heart Journal Supplement. 2001 ; Vol. 2, No. 6. pp. 628-633.
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