Abstract
We investigated the role of atrial natriuretic factor (ANF) in the down-regulation of sodium excretion (UNaV). Seven subjects were sequentially studied while injesting a normal-salt diel (220 mmol NaCl/day, NSD), a very low-salt diet (20 mmol NaCl/day, VLSD) for six days, and again at NSD for nine days. After one day of VLSD, a negative salt balance of 85 mmol was achieved and plasma ANF decreased from 19.1 (SE 2.5) to 7.2 (SE 2.1) pg/ml, whereas plasma renin activity (PRA) and plasma aldosterone (ALD) increased after the third and second day, respectively. During restoration of volemia (NSD), ANF increased after the third day; in contrast, PRA and ALD decreased earlier. Seven other subjects kept at low-salt diet (50 mmol NaCl/day) were studied during ANF infusion (at 2, 4, 8 ng/min/kg body wt). Increases of ANF from 10.3 (SE 0.9) pg/ml (basal condition) to levels of 24.0 (SE 1.9) pg/ml (infusion study), occurring physiologically in the same subjects after NSD, evoked increases in UNaV that accounted for 62% of UNaV rise necessary to balance the NSD, whereas PRA or ALD did not change. Plasma ANF, unlike PRA or ALD, was directly correlated with UNaV. In conclusion: (a) ANF changes earlier than PRA and plasma aldosterone during VLSD; (b) PRA and ALD respond more promptly than ANF in the recovery from hypovolemia; (c) during ingestion of a low-salt diet, changes in plasma ANF by infusion account for more than half the increase in UNaV following the shift from low- to normal-salt diet independently of alterations in PRA and ALD.
| Original language | English |
|---|---|
| Pages (from-to) | 673-680 |
| Number of pages | 8 |
| Journal | Kidney International |
| Volume | 42 |
| Issue number | 3 |
| Publication status | Published - Sep 1992 |
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ASJC Scopus subject areas
- Nephrology
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Role of inhibition of atrial natriuretic factor release in the down-regulation of salt excretion. / Conte, Giuseppe; Romano, Giulio; Sepe, Vincenzo; De Nicola, Luca; Sabbatini, Massimo; Russo, Domenico; Memoli, Bruno; Ungaro, Biagio; Fuiano, Giorgio; Caglioti, Alfredo; Dal Canton, Antonio.
In: Kidney International, Vol. 42, No. 3, 09.1992, p. 673-680.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Role of inhibition of atrial natriuretic factor release in the down-regulation of salt excretion
AU - Conte, Giuseppe
AU - Romano, Giulio
AU - Sepe, Vincenzo
AU - De Nicola, Luca
AU - Sabbatini, Massimo
AU - Russo, Domenico
AU - Memoli, Bruno
AU - Ungaro, Biagio
AU - Fuiano, Giorgio
AU - Caglioti, Alfredo
AU - Dal Canton, Antonio
PY - 1992/9
Y1 - 1992/9
N2 - We investigated the role of atrial natriuretic factor (ANF) in the down-regulation of sodium excretion (UNaV). Seven subjects were sequentially studied while injesting a normal-salt diel (220 mmol NaCl/day, NSD), a very low-salt diet (20 mmol NaCl/day, VLSD) for six days, and again at NSD for nine days. After one day of VLSD, a negative salt balance of 85 mmol was achieved and plasma ANF decreased from 19.1 (SE 2.5) to 7.2 (SE 2.1) pg/ml, whereas plasma renin activity (PRA) and plasma aldosterone (ALD) increased after the third and second day, respectively. During restoration of volemia (NSD), ANF increased after the third day; in contrast, PRA and ALD decreased earlier. Seven other subjects kept at low-salt diet (50 mmol NaCl/day) were studied during ANF infusion (at 2, 4, 8 ng/min/kg body wt). Increases of ANF from 10.3 (SE 0.9) pg/ml (basal condition) to levels of 24.0 (SE 1.9) pg/ml (infusion study), occurring physiologically in the same subjects after NSD, evoked increases in UNaV that accounted for 62% of UNaV rise necessary to balance the NSD, whereas PRA or ALD did not change. Plasma ANF, unlike PRA or ALD, was directly correlated with UNaV. In conclusion: (a) ANF changes earlier than PRA and plasma aldosterone during VLSD; (b) PRA and ALD respond more promptly than ANF in the recovery from hypovolemia; (c) during ingestion of a low-salt diet, changes in plasma ANF by infusion account for more than half the increase in UNaV following the shift from low- to normal-salt diet independently of alterations in PRA and ALD.
AB - We investigated the role of atrial natriuretic factor (ANF) in the down-regulation of sodium excretion (UNaV). Seven subjects were sequentially studied while injesting a normal-salt diel (220 mmol NaCl/day, NSD), a very low-salt diet (20 mmol NaCl/day, VLSD) for six days, and again at NSD for nine days. After one day of VLSD, a negative salt balance of 85 mmol was achieved and plasma ANF decreased from 19.1 (SE 2.5) to 7.2 (SE 2.1) pg/ml, whereas plasma renin activity (PRA) and plasma aldosterone (ALD) increased after the third and second day, respectively. During restoration of volemia (NSD), ANF increased after the third day; in contrast, PRA and ALD decreased earlier. Seven other subjects kept at low-salt diet (50 mmol NaCl/day) were studied during ANF infusion (at 2, 4, 8 ng/min/kg body wt). Increases of ANF from 10.3 (SE 0.9) pg/ml (basal condition) to levels of 24.0 (SE 1.9) pg/ml (infusion study), occurring physiologically in the same subjects after NSD, evoked increases in UNaV that accounted for 62% of UNaV rise necessary to balance the NSD, whereas PRA or ALD did not change. Plasma ANF, unlike PRA or ALD, was directly correlated with UNaV. In conclusion: (a) ANF changes earlier than PRA and plasma aldosterone during VLSD; (b) PRA and ALD respond more promptly than ANF in the recovery from hypovolemia; (c) during ingestion of a low-salt diet, changes in plasma ANF by infusion account for more than half the increase in UNaV following the shift from low- to normal-salt diet independently of alterations in PRA and ALD.
UR - http://www.scopus.com/inward/record.url?scp=0026793565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026793565&partnerID=8YFLogxK
M3 - Article
C2 - 1405345
AN - SCOPUS:0026793565
VL - 42
SP - 673
EP - 680
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 3
ER -