Role of inhibition of atrial natriuretic factor release in the down-regulation of salt excretion

Giuseppe Conte, Giulio Romano, Vincenzo Sepe, Luca De Nicola, Massimo Sabbatini, Domenico Russo, Bruno Memoli, Biagio Ungaro, Giorgio Fuiano, Alfredo Caglioti, Antonio Dal Canton

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Abstract

We investigated the role of atrial natriuretic factor (ANF) in the down-regulation of sodium excretion (UNaV). Seven subjects were sequentially studied while injesting a normal-salt diel (220 mmol NaCl/day, NSD), a very low-salt diet (20 mmol NaCl/day, VLSD) for six days, and again at NSD for nine days. After one day of VLSD, a negative salt balance of 85 mmol was achieved and plasma ANF decreased from 19.1 (SE 2.5) to 7.2 (SE 2.1) pg/ml, whereas plasma renin activity (PRA) and plasma aldosterone (ALD) increased after the third and second day, respectively. During restoration of volemia (NSD), ANF increased after the third day; in contrast, PRA and ALD decreased earlier. Seven other subjects kept at low-salt diet (50 mmol NaCl/day) were studied during ANF infusion (at 2, 4, 8 ng/min/kg body wt). Increases of ANF from 10.3 (SE 0.9) pg/ml (basal condition) to levels of 24.0 (SE 1.9) pg/ml (infusion study), occurring physiologically in the same subjects after NSD, evoked increases in UNaV that accounted for 62% of UNaV rise necessary to balance the NSD, whereas PRA or ALD did not change. Plasma ANF, unlike PRA or ALD, was directly correlated with UNaV. In conclusion: (a) ANF changes earlier than PRA and plasma aldosterone during VLSD; (b) PRA and ALD respond more promptly than ANF in the recovery from hypovolemia; (c) during ingestion of a low-salt diet, changes in plasma ANF by infusion account for more than half the increase in UNaV following the shift from low- to normal-salt diet independently of alterations in PRA and ALD.

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalKidney International
Volume42
Issue number3
Publication statusPublished - Sep 1992

ASJC Scopus subject areas

  • Nephrology

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    Conte, G., Romano, G., Sepe, V., De Nicola, L., Sabbatini, M., Russo, D., Memoli, B., Ungaro, B., Fuiano, G., Caglioti, A., & Dal Canton, A. (1992). Role of inhibition of atrial natriuretic factor release in the down-regulation of salt excretion. Kidney International, 42(3), 673-680.