Abstract
The combined effect of Peroxisome proliferator-activated receptor γ (PPARG) Pro/Ala and interleukin-6 G174C gene variants, was evaluated in 429 Caucasian subjects in order to determine whether subjects carrying both variants were at different risk for obesity. In particular, the combined contribution of these two variants (both independent and interaction effects) to the total variation of obesity-related factors was estimated. All subjects were genotyped for codon 12 Pro/Ala locus variability and for the interleukin-6-174 C/G promoter polymorphism. Subjects with the Ala variant had significantly lower BMI, insulin resistance, triglyceride levels than those without. Furthermore, subjects with Ala variant had significantly lower IL-6 levels (0.88±0.9 vs 1.61±2.25 pg/ml; p=0.041). In contrast, the IL6-C variant was significantly associated with lower plasma IL-6 and with lower total cholesterol levels but was not significantly associated with any other obesity risk factors. Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8±2.3 vs 24.14±1.9; f=5.31; p
| Original language | English |
|---|---|
| Pages (from-to) | 599-604 |
| Number of pages | 6 |
| Journal | Experimental Gerontology |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2005 |
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Keywords
- Body mass index
- Gene polymorphism
- IL-6
- Insulin resistance
- PPARG
ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors. / Barbieri, M.; Rizzo, M. R.; Papa, M.; Acampora, R.; De Angelis, L.; Olivieri, F.; Marchegiani, F.; Franceschi, C.; Paolisso, G.
In: Experimental Gerontology, Vol. 40, No. 7, 07.2005, p. 599-604.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors
AU - Barbieri, M.
AU - Rizzo, M. R.
AU - Papa, M.
AU - Acampora, R.
AU - De Angelis, L.
AU - Olivieri, F.
AU - Marchegiani, F.
AU - Franceschi, C.
AU - Paolisso, G.
PY - 2005/7
Y1 - 2005/7
N2 - The combined effect of Peroxisome proliferator-activated receptor γ (PPARG) Pro/Ala and interleukin-6 G174C gene variants, was evaluated in 429 Caucasian subjects in order to determine whether subjects carrying both variants were at different risk for obesity. In particular, the combined contribution of these two variants (both independent and interaction effects) to the total variation of obesity-related factors was estimated. All subjects were genotyped for codon 12 Pro/Ala locus variability and for the interleukin-6-174 C/G promoter polymorphism. Subjects with the Ala variant had significantly lower BMI, insulin resistance, triglyceride levels than those without. Furthermore, subjects with Ala variant had significantly lower IL-6 levels (0.88±0.9 vs 1.61±2.25 pg/ml; p=0.041). In contrast, the IL6-C variant was significantly associated with lower plasma IL-6 and with lower total cholesterol levels but was not significantly associated with any other obesity risk factors. Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8±2.3 vs 24.14±1.9; f=5.31; p
AB - The combined effect of Peroxisome proliferator-activated receptor γ (PPARG) Pro/Ala and interleukin-6 G174C gene variants, was evaluated in 429 Caucasian subjects in order to determine whether subjects carrying both variants were at different risk for obesity. In particular, the combined contribution of these two variants (both independent and interaction effects) to the total variation of obesity-related factors was estimated. All subjects were genotyped for codon 12 Pro/Ala locus variability and for the interleukin-6-174 C/G promoter polymorphism. Subjects with the Ala variant had significantly lower BMI, insulin resistance, triglyceride levels than those without. Furthermore, subjects with Ala variant had significantly lower IL-6 levels (0.88±0.9 vs 1.61±2.25 pg/ml; p=0.041). In contrast, the IL6-C variant was significantly associated with lower plasma IL-6 and with lower total cholesterol levels but was not significantly associated with any other obesity risk factors. Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8±2.3 vs 24.14±1.9; f=5.31; p
KW - Body mass index
KW - Gene polymorphism
KW - IL-6
KW - Insulin resistance
KW - PPARG
UR - http://www.scopus.com/inward/record.url?scp=23044444817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23044444817&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2005.05.004
DO - 10.1016/j.exger.2005.05.004
M3 - Article
C2 - 16029943
AN - SCOPUS:23044444817
VL - 40
SP - 599
EP - 604
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 7
ER -