Role of interferon alpha-2a in the treatment of polycythemia vera

P. Foa, P. Massaro, S. Ribera, A. Iurlo, C. Mezzanotte, D. Giandalia, A. T. Maiolo

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the effects of recombinant interferon alpha-2a (IFN-alpha) in 36 patients with polycythemia vera (PV) previously treated with phlebotomy and/or conventional cytostatic agents. In each patient, after at least 2 months of discontinuation of any cytotoxic therapy, the hematocrit (Hmt) was first brought to normal value by phlebotomy; IFN-alpha treatment was then begun at a starting dose of 3,000,000 IU s.c. three times a week. Response to treatment, which was assessed monthly, was defined as persistent normalization of Hmt without concomitant phlebotomy; in non-responsive patients the initial IFN-alpha weekly dosage was progressively increased. Twenty patients were responsive with a median duration of response of 7 months (range 2-25+ months); out of these, 7 patients are still under treatment and responsive at 13+, 17+, 20+, 22+, 23+, 25+, 25+ months. These findings indicate that a cohort, although small, of patients with PV (19.4%) are persistently sensitive to IFN-alpha; in this subset of patients, this cytokine can therefore provide a useful treatment option, since, contrary to conventional therapeutic approaches such as radioactive phosphorus, cytostatic agents, or phlebotomy, IFN-alpha is devoid of harmful side effects.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalAmerican Journal of Hematology
Volume48
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • Interferon alpha-2a
  • Myeloproliferative disorders
  • Polycythemia vera

ASJC Scopus subject areas

  • Hematology

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