Ruolo dell'associazione lattosio, arginina e lisina nella riparazione delle fratture. (Studio sperimentale).

Translated title of the contribution: Role of lactose, arginine and lysine combination in fracture healing (an experimental study)

M. Fini, R. Giardino, N. Nicoli Aldini, L. Martini, M. Rocca, F. Bertoni, S. Capelli, G. Cantelli Forti, A. Sapone, A. Rossetti, G. Morrone, G. Giavaresi

Research output: Contribution to journalArticle

Abstract

L-arginine and L-lysine are essential amino acids which seem to possess some properties able to influence bone fractures healing. In fact, they seem to be involved not only in the increase of intestinal calcium adsorption but also in collagen synthesis, in insulin and growth hormone secretion and in osteoblastic activation. So, an experimental in vivo model was carried out by using 50 adult rabbits which, under general anaesthesia, were submitted to an osteotomy of the left fibula. Animals were divided into 5 groups and were daily treated with a mixture of lactose, L-arginine and L-lysine or with the only lactose (control group) at the same dosage as recommended for humans. They were sacrificed after 15, 30, 40, 50 and 60 days for radiological and histological studies. The results of the study showed that the pharmacological mixture containing L-arginine and L-lysine accelerates and ameliorates the healing processes and this positive effect was particularly evident from the 30th day after the osteotomy. We think that these results are linked not only to calcium metabolism but also to different biological properties which positively contribute to a good healing of bone fractures.

Translated title of the contributionRole of lactose, arginine and lysine combination in fracture healing (an experimental study)
Original languageItalian
JournalAnnali Italiani di Chirurgia
Volume67
Issue number1
Publication statusPublished - Jan 1996

ASJC Scopus subject areas

  • Surgery

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    Fini, M., Giardino, R., Nicoli Aldini, N., Martini, L., Rocca, M., Bertoni, F., Capelli, S., Cantelli Forti, G., Sapone, A., Rossetti, A., Morrone, G., & Giavaresi, G. (1996). Ruolo dell'associazione lattosio, arginina e lisina nella riparazione delle fratture. (Studio sperimentale). Annali Italiani di Chirurgia, 67(1).