Abstract
BACKGROUND. Posttransplant combined lamivudine (LAM) and immunoglobulin (HBIg) prophylaxis is the gold standard in the case of single hepatitis B virus (HBV), but is still not recommended in the case of patients coinfected with hepatitis delta virus (HDV). METHODS. We compared two consecutive groups of chronic HDV carriers who survived >6 months after liver transplantation of the risk of recurrence, survival and HBIg requirements: 21 received passive prophylaxis (HBIg group) and 25 were treated with combined prophylaxis (LAM+HBIg group). The immunoprophylaxis schedule was the same in both groups: intramuscular HBIg targeted to maintain anti-HBs levels of >500 IU/L during the first 6 posttransplant months and >200 IU/L thereafter. RESULTS. The mean length of follow-up in the two groups was significantly different (133 vs. 40 months; P
| Original language | English |
|---|---|
| Pages (from-to) | 1341-1344 |
| Number of pages | 4 |
| Journal | Transplantation |
| Volume | 83 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- Hepatitis B virus
- Hepatitis delta virus
- Lamivudine
- Liver transplantation
- Outcome
ASJC Scopus subject areas
- Transplantation
- Immunology
Cite this
Role of lamivudine in the posttransplant prophylaxis of chronic hepatitis B virus and hepatitis delta virus coinfection. / Caccamo, Lucio; Agnelli, Francesca; Reggiani, Paolo; Maggi, Umberto; Donato, M. Francesca; Gatti, Stefano; Paone, Giovanni; Melada, Ernesto; Rossi, Giorgio.
In: Transplantation, Vol. 83, No. 10, 05.2007, p. 1341-1344.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of lamivudine in the posttransplant prophylaxis of chronic hepatitis B virus and hepatitis delta virus coinfection
AU - Caccamo, Lucio
AU - Agnelli, Francesca
AU - Reggiani, Paolo
AU - Maggi, Umberto
AU - Donato, M. Francesca
AU - Gatti, Stefano
AU - Paone, Giovanni
AU - Melada, Ernesto
AU - Rossi, Giorgio
PY - 2007/5
Y1 - 2007/5
N2 - BACKGROUND. Posttransplant combined lamivudine (LAM) and immunoglobulin (HBIg) prophylaxis is the gold standard in the case of single hepatitis B virus (HBV), but is still not recommended in the case of patients coinfected with hepatitis delta virus (HDV). METHODS. We compared two consecutive groups of chronic HDV carriers who survived >6 months after liver transplantation of the risk of recurrence, survival and HBIg requirements: 21 received passive prophylaxis (HBIg group) and 25 were treated with combined prophylaxis (LAM+HBIg group). The immunoprophylaxis schedule was the same in both groups: intramuscular HBIg targeted to maintain anti-HBs levels of >500 IU/L during the first 6 posttransplant months and >200 IU/L thereafter. RESULTS. The mean length of follow-up in the two groups was significantly different (133 vs. 40 months; P
AB - BACKGROUND. Posttransplant combined lamivudine (LAM) and immunoglobulin (HBIg) prophylaxis is the gold standard in the case of single hepatitis B virus (HBV), but is still not recommended in the case of patients coinfected with hepatitis delta virus (HDV). METHODS. We compared two consecutive groups of chronic HDV carriers who survived >6 months after liver transplantation of the risk of recurrence, survival and HBIg requirements: 21 received passive prophylaxis (HBIg group) and 25 were treated with combined prophylaxis (LAM+HBIg group). The immunoprophylaxis schedule was the same in both groups: intramuscular HBIg targeted to maintain anti-HBs levels of >500 IU/L during the first 6 posttransplant months and >200 IU/L thereafter. RESULTS. The mean length of follow-up in the two groups was significantly different (133 vs. 40 months; P
KW - Hepatitis B virus
KW - Hepatitis delta virus
KW - Lamivudine
KW - Liver transplantation
KW - Outcome
UR - http://www.scopus.com/inward/record.url?scp=34249062310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249062310&partnerID=8YFLogxK
U2 - 10.1097/01.tp.0000264001.69308.be
DO - 10.1097/01.tp.0000264001.69308.be
M3 - Article
VL - 83
SP - 1341
EP - 1344
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 10
ER -