Role of lifestyle factors on plasma homocysteine levels in Parkison's disease patients treated with levodopa

Antonio Siniscalchi, Luca Gallelli, Nicola B. Mercuri, Guido Ferreri Ibbadu, Giovambattista De Sarro

Research output: Contribution to journalArticle

Abstract

Many papers documented that Parkinson's disease (PD) patients treated with levodopa (l-dopa) shows elevated plasma homocysteine (Hcy) levels. Several lifestyle factors are able to influence plasma Hcy levels. We review the evidence that l-dopa therapy is related with an increase in plasma Hcy levels and that several behaviours could be able to cause changes in plasma Hcy concentrations. Therefore, there are reasons to suggest that a healthy lifestyle lowering Hcy may prevent this potential iatrogenic complication during l-dopa therapy. Moreover, at present, no controlled prospective studies have evaluated this phenomenon.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalNutritional Neuroscience
Volume9
Issue number1-2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Behaviours
  • Coffee
  • Homocysteine
  • Parkinson's disease patients
  • Smoke
  • Vitamin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Food Science

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