Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare.

Translated title of the contribution: Role of low-frequency neuronal activity in the medulla in the regulation of the cardiovascular system

N. Montano, S. M. Barman, T. Gnecchi-Ruscone, A. Porta, F. Lombardi, A. Malliani

Research output: Contribution to journalArticlepeer-review

Abstract

We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.

Translated title of the contributionRole of low-frequency neuronal activity in the medulla in the regulation of the cardiovascular system
Original languageItalian
Pages (from-to)41-46
Number of pages6
JournalCardiologia
Volume40
Issue number1
Publication statusPublished - Jan 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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