Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare.

Translated title of the contribution: Role of low-frequency neuronal activity in the medulla in the regulation of the cardiovascular system

N. Montano, S. M. Barman, T. Gnecchi-Ruscone, A. Porta, F. Lombardi, A. Malliani

Research output: Contribution to journalArticle

Abstract

We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.

Original languageItalian
Pages (from-to)41-46
Number of pages6
JournalCardiologia
Volume40
Issue number1
Publication statusPublished - Jan 1995

Fingerprint

Cardiovascular System
Arterial Pressure
Blood Pressure
Neurons
Pressoreceptors
Periodicity
Ventilation
Cats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare. / Montano, N.; Barman, S. M.; Gnecchi-Ruscone, T.; Porta, A.; Lombardi, F.; Malliani, A.

In: Cardiologia, Vol. 40, No. 1, 01.1995, p. 41-46.

Research output: Contribution to journalArticle

@article{a24afed103ef4526b753688ac1cd3852,
title = "Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare.",
abstract = "We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55{\%}) units. The same rhythmicity was found in SAP variability in 25 of 45 (55{\%}) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71{\%}) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.",
author = "N. Montano and Barman, {S. M.} and T. Gnecchi-Ruscone and A. Porta and F. Lombardi and A. Malliani",
year = "1995",
month = "1",
language = "Italian",
volume = "40",
pages = "41--46",
journal = "Cardiologia (Rome, Italy)",
issn = "0393-1978",
publisher = "Societa Italiana di Cardiologia",
number = "1",

}

TY - JOUR

T1 - Evidenza di un ritmo a bassa frequenza nella scarica di singoli neuroni del tronco encefalico coinvolti nella regolazione del sistema cardiovascolare.

AU - Montano, N.

AU - Barman, S. M.

AU - Gnecchi-Ruscone, T.

AU - Porta, A.

AU - Lombardi, F.

AU - Malliani, A.

PY - 1995/1

Y1 - 1995/1

N2 - We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.

AB - We recorded discharge activity of 45 single neurons located in the rostral ventrolateral medulla (n = 21), lateral tegmental field (n = 10) and caudal raphe (n = 14) nuclei in baroreceptor-denervated decerebrate cats (n = 27). Autoregressive spectral analysis was performed on neuronal activity and systolic arterial pressure (SAP). The discharges of the recorded neurons were correlated to 2- to 6 Hz oscillations or 10 Hz rhythm present in sympathetic neural discharge. A low frequency (LF) oscillation (0.12 +/- 0.02 Hz) was observed in 25 (55%) units. The same rhythmicity was found in SAP variability in 25 of 45 (55%) recordings. In 21 of these cases the LF in SAP variability was highly correlated to LF in neural activity. Moreover, 32 out of 45 (71%) neurons showed a higher rhythm (HF; 0.34 +/- 0.06 Hz) related to the ventilation rate. These data demonstrate the presence of an LF oscillation in the discharge of single medullary neurons, involved in the regulation of cardiovascular system. This LF component was similar to that detectable in the spectral analysis of SAP variability, thus supporting the hypothesis of a central origin of this rhythm, largely independent of baroreceptor input.

UR - http://www.scopus.com/inward/record.url?scp=0029171681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029171681&partnerID=8YFLogxK

M3 - Articolo

C2 - 8529237

AN - SCOPUS:0029171681

VL - 40

SP - 41

EP - 46

JO - Cardiologia (Rome, Italy)

JF - Cardiologia (Rome, Italy)

SN - 0393-1978

IS - 1

ER -