Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus

Silvia Franceschi, Ettore Bidoli, Eva Negri, Paola Zambon, Renato Talamini, Alberto Ruol, Maria Parpinel, Fabio Levi, Lorenzo Simonato, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Between 1992 and 1997 we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 304 patients (29 women), ages 39-77 years (median age 60 years), with a first incident squamous-cell carcinoma (SCC) of the oesophagus. Controls were 743 patients (150 women), ages 35-77 years (median age 60 years), admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. We derived estimates of daily dietary intake of 15 macronutrients, cholesterol, and 20 micronutrients or minerals from a validated food-frequency questionnaire, including 78 food groups and recipes and 15 questions on individual eating patterns. After allowance for age, gender, area of residence, education, body mass index, physical activity, smoking habit, alcohol consumption and energy intake, most micronutrients were inversely associated with oesophageal SCC risk. Highly significant associations emerged for monounsaturated fatty acids [odds ratio (OR) in highest vs. lowest intake quintile = 0.5]; carotene (OR = 0.3); lutein + zeaxanthin (OR = 0.4); vitamin C (OR = 0.4); and niacin (OR = 0.5). Only retinol appeared to be positively related to risk (OR = 1.9). The effect of the above nutrients, expressed as ORs, appeared to be similar in non-smokers and smokers, and non/light drinkers and heavy drinkers. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)626-631
Number of pages6
JournalInternational Journal of Cancer
Volume86
Issue number5
DOIs
Publication statusPublished - 2000

Fingerprint

Vitamins
Esophagus
Minerals
Squamous Cell Carcinoma
Odds Ratio
Micronutrients
Food
Lutein
Monounsaturated Fatty Acids
Niacin
Carotenoids
Esophageal Neoplasms
Energy Intake
Vitamin A
Alcohol Drinking
Italy
Ascorbic Acid
Habits
Tobacco
Case-Control Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus. / Franceschi, Silvia; Bidoli, Ettore; Negri, Eva; Zambon, Paola; Talamini, Renato; Ruol, Alberto; Parpinel, Maria; Levi, Fabio; Simonato, Lorenzo; La Vecchia, Carlo.

In: International Journal of Cancer, Vol. 86, No. 5, 2000, p. 626-631.

Research output: Contribution to journalArticle

Franceschi, Silvia ; Bidoli, Ettore ; Negri, Eva ; Zambon, Paola ; Talamini, Renato ; Ruol, Alberto ; Parpinel, Maria ; Levi, Fabio ; Simonato, Lorenzo ; La Vecchia, Carlo. / Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus. In: International Journal of Cancer. 2000 ; Vol. 86, No. 5. pp. 626-631.
@article{62b0c58a8c25452a850dc6e1d4e64515,
title = "Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus",
abstract = "Between 1992 and 1997 we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 304 patients (29 women), ages 39-77 years (median age 60 years), with a first incident squamous-cell carcinoma (SCC) of the oesophagus. Controls were 743 patients (150 women), ages 35-77 years (median age 60 years), admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. We derived estimates of daily dietary intake of 15 macronutrients, cholesterol, and 20 micronutrients or minerals from a validated food-frequency questionnaire, including 78 food groups and recipes and 15 questions on individual eating patterns. After allowance for age, gender, area of residence, education, body mass index, physical activity, smoking habit, alcohol consumption and energy intake, most micronutrients were inversely associated with oesophageal SCC risk. Highly significant associations emerged for monounsaturated fatty acids [odds ratio (OR) in highest vs. lowest intake quintile = 0.5]; carotene (OR = 0.3); lutein + zeaxanthin (OR = 0.4); vitamin C (OR = 0.4); and niacin (OR = 0.5). Only retinol appeared to be positively related to risk (OR = 1.9). The effect of the above nutrients, expressed as ORs, appeared to be similar in non-smokers and smokers, and non/light drinkers and heavy drinkers. (C) 2000 Wiley-Liss, Inc.",
author = "Silvia Franceschi and Ettore Bidoli and Eva Negri and Paola Zambon and Renato Talamini and Alberto Ruol and Maria Parpinel and Fabio Levi and Lorenzo Simonato and {La Vecchia}, Carlo",
year = "2000",
doi = "10.1002/(SICI)1097-0215(20000601)86:5<626::AID-IJC4>3.0.CO;2-Y",
language = "English",
volume = "86",
pages = "626--631",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Role of macronutrients, vitamins and minerals in tile aetiology of squamous-cell carcinoma of the oesophagus

AU - Franceschi, Silvia

AU - Bidoli, Ettore

AU - Negri, Eva

AU - Zambon, Paola

AU - Talamini, Renato

AU - Ruol, Alberto

AU - Parpinel, Maria

AU - Levi, Fabio

AU - Simonato, Lorenzo

AU - La Vecchia, Carlo

PY - 2000

Y1 - 2000

N2 - Between 1992 and 1997 we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 304 patients (29 women), ages 39-77 years (median age 60 years), with a first incident squamous-cell carcinoma (SCC) of the oesophagus. Controls were 743 patients (150 women), ages 35-77 years (median age 60 years), admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. We derived estimates of daily dietary intake of 15 macronutrients, cholesterol, and 20 micronutrients or minerals from a validated food-frequency questionnaire, including 78 food groups and recipes and 15 questions on individual eating patterns. After allowance for age, gender, area of residence, education, body mass index, physical activity, smoking habit, alcohol consumption and energy intake, most micronutrients were inversely associated with oesophageal SCC risk. Highly significant associations emerged for monounsaturated fatty acids [odds ratio (OR) in highest vs. lowest intake quintile = 0.5]; carotene (OR = 0.3); lutein + zeaxanthin (OR = 0.4); vitamin C (OR = 0.4); and niacin (OR = 0.5). Only retinol appeared to be positively related to risk (OR = 1.9). The effect of the above nutrients, expressed as ORs, appeared to be similar in non-smokers and smokers, and non/light drinkers and heavy drinkers. (C) 2000 Wiley-Liss, Inc.

AB - Between 1992 and 1997 we conducted a case-control study of oesophageal cancer in 3 areas of northern Italy. Cases were 304 patients (29 women), ages 39-77 years (median age 60 years), with a first incident squamous-cell carcinoma (SCC) of the oesophagus. Controls were 743 patients (150 women), ages 35-77 years (median age 60 years), admitted for acute illnesses, unrelated to tobacco and alcohol, to major hospitals of the areas under surveillance. We derived estimates of daily dietary intake of 15 macronutrients, cholesterol, and 20 micronutrients or minerals from a validated food-frequency questionnaire, including 78 food groups and recipes and 15 questions on individual eating patterns. After allowance for age, gender, area of residence, education, body mass index, physical activity, smoking habit, alcohol consumption and energy intake, most micronutrients were inversely associated with oesophageal SCC risk. Highly significant associations emerged for monounsaturated fatty acids [odds ratio (OR) in highest vs. lowest intake quintile = 0.5]; carotene (OR = 0.3); lutein + zeaxanthin (OR = 0.4); vitamin C (OR = 0.4); and niacin (OR = 0.5). Only retinol appeared to be positively related to risk (OR = 1.9). The effect of the above nutrients, expressed as ORs, appeared to be similar in non-smokers and smokers, and non/light drinkers and heavy drinkers. (C) 2000 Wiley-Liss, Inc.

UR - http://www.scopus.com/inward/record.url?scp=0034060295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034060295&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0215(20000601)86:5<626::AID-IJC4>3.0.CO;2-Y

DO - 10.1002/(SICI)1097-0215(20000601)86:5<626::AID-IJC4>3.0.CO;2-Y

M3 - Article

C2 - 10797282

AN - SCOPUS:0034060295

VL - 86

SP - 626

EP - 631

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 5

ER -