Role of macrophage metalloelastase in gut inflammation

Sylvia L F Pender, C. K F Li, A. D I Sabatino, T. T. Macdonald, M. G. Buckley

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages3
Publication statusPublished - 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Immune response
  • Inflammatory bowel diseases
  • Intestine
  • Macrophages
  • Matrix metalloproteinase
  • Tissue inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Role of macrophage metalloelastase in gut inflammation'. Together they form a unique fingerprint.

Cite this