Role of macrophage metalloelastase in gut inflammation

Sylvia L F Pender, C. K F Li, A. D I Sabatino, T. T. Macdonald, M. G. Buckley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages386-388
Number of pages3
Volume1072
DOIs
Publication statusPublished - 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1072
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Immune response
  • Inflammatory bowel diseases
  • Intestine
  • Macrophages
  • Matrix metalloproteinase
  • Tissue inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Pender, S. L. F., Li, C. K. F., Sabatino, A. D. I., Macdonald, T. T., & Buckley, M. G. (2006). Role of macrophage metalloelastase in gut inflammation. In Annals of the New York Academy of Sciences (Vol. 1072, pp. 386-388). (Annals of the New York Academy of Sciences; Vol. 1072). https://doi.org/10.1196/annals.1326.019