Role of Magnesium, Coenzyme Q10, Riboflavin, and Vitamin B12 in Migraine Prophylaxis

Alfredo Bianchi, Salvatore Salomone, Filippo Caraci, Vincenzo Pizza, Renato Bernardini, Cesare Colucci D'Amato

Research output: Chapter in Book/Report/Conference proceedingChapter


Migraine is a neurovascular syndrome characterized by recurrent headache associated with other symptoms, eventually preceded by aura. This chapter reviews the involvement of some mineral, coenzyme, and vitamin defects in the pathogenesis of migraine headaches and focuses on their potential therapeutic use in the preventive treatment for migraine. The therapeutic potential of magnesium, coenzyme Q10, riboflavin, and vitamin B12 can be cautiously inferred from some published open clinical trials; it should, however, be considered that double-blind randomized larger studies are needed to correctly estimate the impact of the placebo effect in these promising therapies.

Original languageEnglish
Title of host publicationVitamins and Hormones
Number of pages16
Publication statusPublished - 2004

Publication series

NameVitamins and Hormones
ISSN (Print)00836729

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Endocrinology
  • Physiology


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