Ruolo della risonanza magnetica come fattore predittivo della risposta tumorale a chemioterapia neoadiuvante in pazienti con carcinoma della mammella localmente avanzato

Translated title of the contribution: Role of magnetic resonance imaging in the prediction of tumor response in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy

Laura Martincich, Filippo Montemurro, Stefano Cirillo, Vincenzo Marra, Giovanni De Rosa, Riccardo Ponzone, Massimo Aglietta, Daniele Regge

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. To evaluate if dynamic contrast enhanced magnetic resonance can predict the tumoural response in patients with breast cancer undergoing neoadjuvant chemotherapy. Materials and methods. Twenty-six patients with biopsy-proven locally advanced breast cancer underwent taxane-based neoadjuvant chemotherapy followed by radical surgery. MRI evaluations were carried out at baseline, after two of the four planned cycles of chemotherapy, and before surgical treatment. MR images, obtained with 1.5 T scanner and using dedicated surface multichannel coil (GEMS), were acquired by 3D SPGR sequences on the coronal plane before and after intravenous administration of gadolinium chelate by an automatic injector. The percent reduction of the early contrast uptake between the baseline and the second MRI was then calculated for every lesion and correlated with the outcome of interest (pCR). Results. At baseline, we identified 26 lesions and two patterns of MRI enhancement: homogeneous (group 1, 14 patients) and peripheral ring-like (group 2, 12 patients). At surgery, pathological complete response was observed in 4 patients (2 patients group 1, 2 patients group 2). In group 1, the 2 cases of pCR showed a ≥70% reduction in the early contrast uptake between baseline examination and after two cycles of chemotherapy, whereas values

Translated title of the contributionRole of magnetic resonance imaging in the prediction of tumor response in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy
Original languageItalian
Pages (from-to)51-58
Number of pages8
JournalRadiologia Medica
Volume106
Issue number1-2
Publication statusPublished - Jul 2003

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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