Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients

S. De Iudicibus, G. Castronovo, A. Gigante, G. Stocco, G. Decorti, R. Di Lenarda, F. Bartoli

Research output: Contribution to journalArticle

Abstract

Background and Objective: The aim of the present study was to determine the association between genotypes of the MDR1 gene, encoding P-glycoprotein, and gingival overgrowth in transplant patients treated with cyclosporine, and to evaluate the effect of periodontal treatment in these patients. Material and Methods: Fifty transplant patients receiving therapy with cyclosporine and suffering from gingival overgrowth were subjected to nonsurgical periodontal treatment and received oral hygiene instructions. Hyperplastic index, periodontal probing depths, bleeding and plaque scores were recorded at baseline and after 3 and 6 mo. Patients were dichotomized into two groups: those with a hyperplastic index of <30% (minimal gingival overgrowth) and those with a hyperplastic index of ≥ 30% (clinically significant gingival overgrowth). MDR1 C3435T and G2677T polymorphisms were evaluated in all patients and in 100 controls. Results: At baseline, 32 patients (64%) had minimal gingival overgrowth and 18 patients (36%) had clinically significant gingival overgrowth. The mutated C3435T genotype was significantly more frequent in the second group (p <0.019). The significant association between gingival overgrowth and the 3435TT genotype was confirmed by logistic regression analysis (p <0.031). The differences in hyperplastic index, observed at baseline between patients with the TT genotype and those with the CC/CT genotype disappeared in the second and third evaluation. The mean monthly change of the square root of the gingival overgrowth scores for all patients, assessed using linear models, was significantly different from baseline (-0.17 points per month, p <0.00001); and this was particularly evident in subjects with renal transplant (-1.62, p <0.01). Conclusion: Aetiological periodontal and self-performed maintenance therapy is effective in reducing gingival overgrowth, particularly in subjects with the 3435TT genotype and in patients with renal transplant.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalJournal of Periodontal Research
Volume43
Issue number6
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Gingival Overgrowth
Cyclosporine
Transplants
Genes
Genotype
Kidney
Periodontal Index
Oral Hygiene
P-Glycoprotein
Therapeutics
Linear Models

Keywords

  • Cyclosporine A
  • Gingival overgrowth
  • MDR1 gene polymorphisms
  • Non surgical aetiological periodontal therapy

ASJC Scopus subject areas

  • Periodontics

Cite this

De Iudicibus, S., Castronovo, G., Gigante, A., Stocco, G., Decorti, G., Di Lenarda, R., & Bartoli, F. (2008). Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients. Journal of Periodontal Research, 43(6), 665-672. https://doi.org/10.1111/j.1600-0765.2008.01068.x

Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients. / De Iudicibus, S.; Castronovo, G.; Gigante, A.; Stocco, G.; Decorti, G.; Di Lenarda, R.; Bartoli, F.

In: Journal of Periodontal Research, Vol. 43, No. 6, 12.2008, p. 665-672.

Research output: Contribution to journalArticle

De Iudicibus, S, Castronovo, G, Gigante, A, Stocco, G, Decorti, G, Di Lenarda, R & Bartoli, F 2008, 'Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients', Journal of Periodontal Research, vol. 43, no. 6, pp. 665-672. https://doi.org/10.1111/j.1600-0765.2008.01068.x
De Iudicibus, S. ; Castronovo, G. ; Gigante, A. ; Stocco, G. ; Decorti, G. ; Di Lenarda, R. ; Bartoli, F. / Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients. In: Journal of Periodontal Research. 2008 ; Vol. 43, No. 6. pp. 665-672.
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abstract = "Background and Objective: The aim of the present study was to determine the association between genotypes of the MDR1 gene, encoding P-glycoprotein, and gingival overgrowth in transplant patients treated with cyclosporine, and to evaluate the effect of periodontal treatment in these patients. Material and Methods: Fifty transplant patients receiving therapy with cyclosporine and suffering from gingival overgrowth were subjected to nonsurgical periodontal treatment and received oral hygiene instructions. Hyperplastic index, periodontal probing depths, bleeding and plaque scores were recorded at baseline and after 3 and 6 mo. Patients were dichotomized into two groups: those with a hyperplastic index of <30{\%} (minimal gingival overgrowth) and those with a hyperplastic index of ≥ 30{\%} (clinically significant gingival overgrowth). MDR1 C3435T and G2677T polymorphisms were evaluated in all patients and in 100 controls. Results: At baseline, 32 patients (64{\%}) had minimal gingival overgrowth and 18 patients (36{\%}) had clinically significant gingival overgrowth. The mutated C3435T genotype was significantly more frequent in the second group (p <0.019). The significant association between gingival overgrowth and the 3435TT genotype was confirmed by logistic regression analysis (p <0.031). The differences in hyperplastic index, observed at baseline between patients with the TT genotype and those with the CC/CT genotype disappeared in the second and third evaluation. The mean monthly change of the square root of the gingival overgrowth scores for all patients, assessed using linear models, was significantly different from baseline (-0.17 points per month, p <0.00001); and this was particularly evident in subjects with renal transplant (-1.62, p <0.01). Conclusion: Aetiological periodontal and self-performed maintenance therapy is effective in reducing gingival overgrowth, particularly in subjects with the 3435TT genotype and in patients with renal transplant.",
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AU - De Iudicibus, S.

AU - Castronovo, G.

AU - Gigante, A.

AU - Stocco, G.

AU - Decorti, G.

AU - Di Lenarda, R.

AU - Bartoli, F.

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AB - Background and Objective: The aim of the present study was to determine the association between genotypes of the MDR1 gene, encoding P-glycoprotein, and gingival overgrowth in transplant patients treated with cyclosporine, and to evaluate the effect of periodontal treatment in these patients. Material and Methods: Fifty transplant patients receiving therapy with cyclosporine and suffering from gingival overgrowth were subjected to nonsurgical periodontal treatment and received oral hygiene instructions. Hyperplastic index, periodontal probing depths, bleeding and plaque scores were recorded at baseline and after 3 and 6 mo. Patients were dichotomized into two groups: those with a hyperplastic index of <30% (minimal gingival overgrowth) and those with a hyperplastic index of ≥ 30% (clinically significant gingival overgrowth). MDR1 C3435T and G2677T polymorphisms were evaluated in all patients and in 100 controls. Results: At baseline, 32 patients (64%) had minimal gingival overgrowth and 18 patients (36%) had clinically significant gingival overgrowth. The mutated C3435T genotype was significantly more frequent in the second group (p <0.019). The significant association between gingival overgrowth and the 3435TT genotype was confirmed by logistic regression analysis (p <0.031). The differences in hyperplastic index, observed at baseline between patients with the TT genotype and those with the CC/CT genotype disappeared in the second and third evaluation. The mean monthly change of the square root of the gingival overgrowth scores for all patients, assessed using linear models, was significantly different from baseline (-0.17 points per month, p <0.00001); and this was particularly evident in subjects with renal transplant (-1.62, p <0.01). Conclusion: Aetiological periodontal and self-performed maintenance therapy is effective in reducing gingival overgrowth, particularly in subjects with the 3435TT genotype and in patients with renal transplant.

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