Role of metabolism in neurodegenerative disorders

Claudio Procaccini, Marianna Santopaolo, Deriggio Faicchia, Alessandra Colamatteo, Luigi Formisano, Paola De Candia, Mario Galgani, Veronica De Rosa, Giuseppe Matarese

Research output: Contribution to journalArticlepeer-review


Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases.

Original languageEnglish
Pages (from-to)1376-1390
Number of pages15
JournalMetabolism: Clinical and Experimental
Issue number9
Publication statusPublished - Sep 1 2016


  • Alzheimer's disease
  • Huntington's diseases
  • Metabolism
  • Multiple sclerosis
  • Parkinson's disease

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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