TY - JOUR
T1 - Role of metabolism in neurodegenerative disorders
AU - Procaccini, C.
AU - Santopaolo, Marianna
AU - Faicchia, Deriggio
AU - Colamatteo, Alessandra
AU - Formisano, Luigi
AU - De Candia, Paola
AU - Galgani, Mario
AU - De Rosa, Veronica
AU - Matarese, Giuseppe
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases.
AB - Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases.
KW - Alzheimer's disease
KW - Huntington's diseases
KW - Metabolism
KW - Multiple sclerosis
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=84975231228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975231228&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2016.05.018
DO - 10.1016/j.metabol.2016.05.018
M3 - Article
VL - 65
SP - 1376
EP - 1390
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 9
ER -