AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO

Translated title of the contribution: Role of metabotropic receptor

M. Pizzi, V. Arrighi, O. Consolandi, M. Memo, P. F. Spano

Research output: Contribution to journalArticle

Abstract

Activation of glutamate ionotropic receptors represents the primary event in the neurotoxicity process triggered by excitatory amino acids. We demonstrate here that the concentration-dependent stimulation of metabotropic receptor by the selective agonist trans-1-aminocyclopentane-1,3-dicarboxylate (tACPD) counteracts the glutamate-induced neurotoxicity in primary culture of rat cerebellar granule cells. The metabotropic receptor-evoked responses are potentiated by aniracetam, which per se also elicits neuroprotection.

Original languageItalian
Pages (from-to)539-542
Number of pages4
JournalGiornale di Gerontologia
Volume41
Issue number11
Publication statusPublished - 1993

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aniracetam
Ionotropic Glutamate Receptors
Excitatory Amino Acids
Glutamic Acid
1-amino-1,3-dicarboxycyclopentane
Neuroprotection

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Pizzi, M., Arrighi, V., Consolandi, O., Memo, M., & Spano, P. F. (1993). AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO. Giornale di Gerontologia, 41(11), 539-542.

AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO. / Pizzi, M.; Arrighi, V.; Consolandi, O.; Memo, M.; Spano, P. F.

In: Giornale di Gerontologia, Vol. 41, No. 11, 1993, p. 539-542.

Research output: Contribution to journalArticle

Pizzi, M, Arrighi, V, Consolandi, O, Memo, M & Spano, PF 1993, 'AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO', Giornale di Gerontologia, vol. 41, no. 11, pp. 539-542.
Pizzi M, Arrighi V, Consolandi O, Memo M, Spano PF. AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO. Giornale di Gerontologia. 1993;41(11):539-542.
Pizzi, M. ; Arrighi, V. ; Consolandi, O. ; Memo, M. ; Spano, P. F. / AZIONE NEUROPROTETTIVA DEL RECETTORE METABOTROPICO PER IL GLUTAMMATO. In: Giornale di Gerontologia. 1993 ; Vol. 41, No. 11. pp. 539-542.
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