Role of metal ions in the Aβ oligomerization in Alzheimer's disease and in other neurological disorders

D. Drago, S. Bolognin, P. Zatta

Research output: Contribution to journalArticle

Abstract

Neurodegeneration is a complex and multifaceted process leading to many chronic diseased states. Neurodegenerative disorders include a number of different pathological conditions, like Alzheimer's and Parkinson's diseases, which share similar critical metabolic processes, such as protein aggregation, which could be affected by some metal ions. A huge number of reports indicate that, among putative aggravating factors, metal ions (Al, Zn, Cu, Fe) could specifically impair protein aggregation of Aβ, prion protein, ataxin, huntingtin, etc. and their oligomeric toxicity. While studying the molecular basis of these diseases, it has become clear that protein conformation plays a critical role in the pathogenic process. In this review, we will focus on Alzheimer's disease and on the role of metal ions, specifically aluminium, in affecting amyloid aggregation, oligomerization and toxicity.

Original languageEnglish
Pages (from-to)500-507
Number of pages8
JournalCurrent Alzheimer Research
Volume5
Issue number6
DOIs
Publication statusPublished - Dec 2008

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Keywords

  • Aggregation
  • Alzheimer's disease
  • Amyloid
  • Metal ions
  • Oligomers

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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