Role of metalloproteinases in rotator cuff tear

Raffaele Garofalo, Eugenio Cesari, Enzo Vinci, Alessandro Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPS) in the pathophysiology of rotator cuff tears has not been established yet. Recent advances empathize about the role of MMPs and TIMPS in extracellular matrix (ECM) remodeling and degradation in rotator cuff tears pathogenesis and healing after surgical repair. An increase in MMPs synthesis and the resulting MMPs mediated alterations in the ECM of tendons have been implicated in the etiopathogenesis of tendinopathy, and there is an increase in the expression of MMPs and a decrease in TIMP messenger ribonucleic acid expression in tenocytes from degenerative or ruptured tendons. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and bisphosphonates. A better understanding of relationship and activity of these molecules could provide better strategies to optimize outcomes of rotator cuff therapy.

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalSports Medicine and Arthroscopy Review
Volume19
Issue number3
DOIs
Publication statusPublished - Sep 2011

Keywords

  • collagenases
  • extracellular matrix
  • metalloproteinases
  • rotator cuff tear
  • shoulder pain
  • zinc endopeptidases

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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