Role of microRNA in response to ionizing radiations

Evidences and potential impact on clinical practice for radiotherapy

Francesco Cellini, Alessio G. Morganti, Domenico Genovesi, Nicola Silvestris, Vincenzo Valentini

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

MicroRNAs (miRNA) are small, non-coding, RNAs with gene expression regulator roles. As an important class of regulators of many cellular pathways, miRNAs are involved in many signaling pathways and DNA damage repair processes, affecting cellular radiosensitivity. Their role has led to interest in oncological implications to improve treatment results. MiRNAs represent a great opportunity to enhance the efficacy of radiotherapy treatments-they can be used to profile the radioresistance of tumors before radiotherapy, monitor their response throughout the treatment, thus helping to select intensification strategies, and also to define the final response to therapy along with risks of recurrence or metastatization. Even though many interesting studies support such potential, nowadays most studies on patient data are limited to experiments profiling tumor aggressiveness and response to radiotherapy. Moreover many studies report different although not conflicting results on the miRNAs evaluated for each tumor type. Without doubt, the clinical potential of such molecules for radiotherapy is striking and of high interest.

Original languageEnglish
Pages (from-to)5379-5401
Number of pages23
JournalMolecules
Volume19
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Ionizing radiation
Radiotherapy
Ionizing Radiation
MicroRNAs
Tumors
Small Untranslated RNA
Neoplasms
Radiation Tolerance
Gene expression
DNA Repair
DNA Damage
Repair
Therapeutics
Gene Expression
Recurrence
Molecules
DNA
Experiments

Keywords

  • DNA damage repair
  • MicroRNA
  • MiRNA
  • MiRNAs
  • Radiation
  • Radiosensibilization
  • Radiotherapy
  • Resistance
  • Review
  • Tumor

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Role of microRNA in response to ionizing radiations : Evidences and potential impact on clinical practice for radiotherapy. / Cellini, Francesco; Morganti, Alessio G.; Genovesi, Domenico; Silvestris, Nicola; Valentini, Vincenzo.

In: Molecules, Vol. 19, No. 4, 2014, p. 5379-5401.

Research output: Contribution to journalArticle

Cellini, Francesco ; Morganti, Alessio G. ; Genovesi, Domenico ; Silvestris, Nicola ; Valentini, Vincenzo. / Role of microRNA in response to ionizing radiations : Evidences and potential impact on clinical practice for radiotherapy. In: Molecules. 2014 ; Vol. 19, No. 4. pp. 5379-5401.
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