TY - JOUR
T1 - Role of MicroRNAs in lung cancer
T2 - MicroRNA signatures in cancer prognosis
AU - Boeri, Mattia
AU - Pastorino, Ugo
AU - Sozzi, Gabriella
PY - 2012/5
Y1 - 2012/5
N2 - Lung cancer-related mortality is the most common cause of cancer death worldwide. Detecting lung cancer at an earlier stage and, ideally, predicting who will develop the disease and particularly the most aggressive forms of cancer are the biggest challenge. MicroRNAs (miRNAs) are short, noncoding RNA molecules with regulatory function on protein-coding genes. Because of their fundamental role in development and differentiation, their involvement in the biological mechanisms underlying tumorigenesis, as well as their low complexity, stability, and easy detection, they represent a promising class of tissue- and blood-based biomarkers of cancer. We summarize the current literature on the use of microRNAs as diagnostic and prognostic tools in lung cancer and discuss the relevant clinical implications of these findings.
AB - Lung cancer-related mortality is the most common cause of cancer death worldwide. Detecting lung cancer at an earlier stage and, ideally, predicting who will develop the disease and particularly the most aggressive forms of cancer are the biggest challenge. MicroRNAs (miRNAs) are short, noncoding RNA molecules with regulatory function on protein-coding genes. Because of their fundamental role in development and differentiation, their involvement in the biological mechanisms underlying tumorigenesis, as well as their low complexity, stability, and easy detection, they represent a promising class of tissue- and blood-based biomarkers of cancer. We summarize the current literature on the use of microRNAs as diagnostic and prognostic tools in lung cancer and discuss the relevant clinical implications of these findings.
KW - biomarkers
KW - Lung cancer
KW - microRNA
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=84862211160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862211160&partnerID=8YFLogxK
U2 - 10.1097/PPO.0b013e318258b743
DO - 10.1097/PPO.0b013e318258b743
M3 - Article
C2 - 22647364
AN - SCOPUS:84862211160
VL - 18
SP - 268
EP - 274
JO - Cancer Journal from Scientific American
JF - Cancer Journal from Scientific American
SN - 1528-9117
IS - 3
ER -