Role of MicroRNAs in lung cancer: MicroRNA signatures in cancer prognosis

Research output: Contribution to journalArticlepeer-review

Abstract

Lung cancer-related mortality is the most common cause of cancer death worldwide. Detecting lung cancer at an earlier stage and, ideally, predicting who will develop the disease and particularly the most aggressive forms of cancer are the biggest challenge. MicroRNAs (miRNAs) are short, noncoding RNA molecules with regulatory function on protein-coding genes. Because of their fundamental role in development and differentiation, their involvement in the biological mechanisms underlying tumorigenesis, as well as their low complexity, stability, and easy detection, they represent a promising class of tissue- and blood-based biomarkers of cancer. We summarize the current literature on the use of microRNAs as diagnostic and prognostic tools in lung cancer and discuss the relevant clinical implications of these findings.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalCancer Journal (United States)
Volume18
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • biomarkers
  • Lung cancer
  • microRNA
  • prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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