Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Amir Abbas Momtazi, Giuseppe Derosa, Pamela Maffioli, Maciej Banach, Amirhossein Sahebkar

Research output: Contribution to journalReview articlepeer-review

Abstract

Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

Original languageEnglish
Pages (from-to)335-345
Number of pages11
JournalMolecular Diagnosis and Therapy
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Medicine(all)
  • Pharmacology

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