Role of mitogen-activated protein kinase pathways in multifactorial adverse cardiac remodeling associated with metabolic syndrome

Mohamed Asrih, François MacH, Alessio Nencioni, Franco Dallegri, Alessandra Quercioli, Fabrizio Montecucco

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Metabolic syndrome has been widely associated with an increased risk for acute cardiovascular events. Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure. This pathological remodeling has been described to result from the cardiac adaptive response to clinical mechanical conditions (such as hypertension, dyslipidemia, and hyperglycemia), soluble inflammatory molecules (such as cytokines and chemokines), as well as hormones (such as insulin), characterizing the pathophysiology of metabolic syndrome. Moreover, these cardiac processes (resulting in cardiac hypertrophy and fibrosis) are also associated with the modulation of intracellular signalling pathways within cardiomyocytes. Amongst the different intracellular kinases, mitogen-activated protein kinases (MAPKs) were shown to be involved in heart damage in metabolic syndrome. However, their role remains controversial. In this paper, we will discuss and update evidence on MAPK-mediated mechanisms underlying cardiac adverse remodeling associated with metabolic syndrome.

Original languageEnglish
Article number367245
JournalMediators of Inflammation
Volume2013
DOIs
Publication statusPublished - 2013

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Mitogen-Activated Protein Kinases
Cardiomegaly
Dyslipidemias
Chemokines
Cardiac Myocytes
Hyperglycemia
Fibrosis
Phosphotransferases
Heart Failure
Hormones
Insulin
Cytokines
Hypertension

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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Role of mitogen-activated protein kinase pathways in multifactorial adverse cardiac remodeling associated with metabolic syndrome. / Asrih, Mohamed; MacH, François; Nencioni, Alessio; Dallegri, Franco; Quercioli, Alessandra; Montecucco, Fabrizio.

In: Mediators of Inflammation, Vol. 2013, 367245, 2013.

Research output: Contribution to journalArticle

Asrih, Mohamed ; MacH, François ; Nencioni, Alessio ; Dallegri, Franco ; Quercioli, Alessandra ; Montecucco, Fabrizio. / Role of mitogen-activated protein kinase pathways in multifactorial adverse cardiac remodeling associated with metabolic syndrome. In: Mediators of Inflammation. 2013 ; Vol. 2013.
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