Role of mTOR Signaling in Tumor Microenvironment: An Overview

F. Conciatori, C. Bazzichetto, I. Falcone, S. Pilotto, E. Bria, F. Cognetti, M. Milella, L. Ciuffreda

Research output: Contribution to journalArticle

Abstract

The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME's elements and their implications in cancer immunotherapy.
Original languageEnglish
Pages (from-to)pii: E2453
JournalInternational Journal of Molecular Sciences
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 19 2018

Fingerprint

Tumor Microenvironment
Sirolimus
Tumors
tumors
Neoplasms
cancer
angiogenesis
Drug Resistance
Chemical activation
Immunotherapy
Cells
cues
immunity
Cues
Immunity
therapy
drugs
activation
Pharmaceutical Preparations
interactions

Keywords

  • angiogenesis
  • immunotherapy
  • mTOR
  • tumor microenvironment

Cite this

Conciatori, F., Bazzichetto, C., Falcone, I., Pilotto, S., Bria, E., Cognetti, F., ... Ciuffreda, L. (2018). Role of mTOR Signaling in Tumor Microenvironment: An Overview. International Journal of Molecular Sciences, 19(8), pii: E2453. https://doi.org/10.3390/ijms19082453

Role of mTOR Signaling in Tumor Microenvironment: An Overview. / Conciatori, F.; Bazzichetto, C.; Falcone, I.; Pilotto, S.; Bria, E.; Cognetti, F.; Milella, M.; Ciuffreda, L.

In: International Journal of Molecular Sciences, Vol. 19, No. 8, 19.08.2018, p. pii: E2453.

Research output: Contribution to journalArticle

Conciatori, F, Bazzichetto, C, Falcone, I, Pilotto, S, Bria, E, Cognetti, F, Milella, M & Ciuffreda, L 2018, 'Role of mTOR Signaling in Tumor Microenvironment: An Overview', International Journal of Molecular Sciences, vol. 19, no. 8, pp. pii: E2453. https://doi.org/10.3390/ijms19082453
Conciatori, F. ; Bazzichetto, C. ; Falcone, I. ; Pilotto, S. ; Bria, E. ; Cognetti, F. ; Milella, M. ; Ciuffreda, L. / Role of mTOR Signaling in Tumor Microenvironment: An Overview. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 8. pp. pii: E2453.
@article{3d742498e33041a7b1b9ba99eb7fa37d,
title = "Role of mTOR Signaling in Tumor Microenvironment: An Overview",
abstract = "The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME's elements and their implications in cancer immunotherapy.",
keywords = "angiogenesis, immunotherapy, mTOR, tumor microenvironment",
author = "F. Conciatori and C. Bazzichetto and I. Falcone and S. Pilotto and E. Bria and F. Cognetti and M. Milella and L. Ciuffreda",
note = "LR: 20180909; JID: 101092791; OTO: NOTNLM; 2018/07/11 00:00 [received]; 2018/08/06 00:00 [revised]; 2018/08/15 00:00 [accepted]; 2018/08/22 06:00 [entrez]; 2018/08/22 06:00 [pubmed]; 2018/08/22 06:00 [medline]; epublish",
year = "2018",
month = "8",
day = "19",
doi = "10.3390/ijms19082453",
language = "English",
volume = "19",
pages = "pii: E2453",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "8",

}

TY - JOUR

T1 - Role of mTOR Signaling in Tumor Microenvironment: An Overview

AU - Conciatori, F.

AU - Bazzichetto, C.

AU - Falcone, I.

AU - Pilotto, S.

AU - Bria, E.

AU - Cognetti, F.

AU - Milella, M.

AU - Ciuffreda, L.

N1 - LR: 20180909; JID: 101092791; OTO: NOTNLM; 2018/07/11 00:00 [received]; 2018/08/06 00:00 [revised]; 2018/08/15 00:00 [accepted]; 2018/08/22 06:00 [entrez]; 2018/08/22 06:00 [pubmed]; 2018/08/22 06:00 [medline]; epublish

PY - 2018/8/19

Y1 - 2018/8/19

N2 - The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME's elements and their implications in cancer immunotherapy.

AB - The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME's elements and their implications in cancer immunotherapy.

KW - angiogenesis

KW - immunotherapy

KW - mTOR

KW - tumor microenvironment

U2 - 10.3390/ijms19082453

DO - 10.3390/ijms19082453

M3 - Article

VL - 19

SP - pii: E2453

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 8

ER -