TY - JOUR
T1 - Role of mucosal high-risk human papillomavirus types in head and neck cancers in central India
AU - Gheit, Tarik
AU - Anantharaman, Devasena
AU - Holzinger, Dana
AU - Alemany, Laia
AU - Tous, Sara
AU - Lucas, Eric
AU - Prabhu, Priya Ramesh
AU - Pawlita, Michael
AU - Ridder, Ruediger
AU - Rehm, Susanne
AU - Bogers, Johannes
AU - Maffini, Fausto
AU - Chiocca, Susanna
AU - Lloveras, Belén
AU - Kumar, Rekha Vijay
AU - Somanathan, Thara
AU - de Sanjosé, Silvia
AU - Castellsagué, Xavier
AU - Arbyn, Marc
AU - Brennan, Paul
AU - Sankaranarayanan, Rengaswamy
AU - Pillai, Madhavan Radhakrishna
AU - Gangane, Nitin
AU - Tommasino, Massimo
AU - the HPV-AHEAD study group
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59). In this retrospective study, HPV-driven HNC were defined by presence of both viral DNA and RNA. Overexpression of p16INK4a was also evaluated. HR-HPV DNA was detected in 13.7% of the cases; however, only 2.7% were positive for both HPV DNA and RNA. The highest percentage of HPV DNA/RNA double positivity was found in oropharynx (9.4%), followed by larynx (1.7%) and oral cavity (1.6%) (p = 0.02). More than half of HPV DNA/RNA-positive cases were p16INK4a-negative, while a considerable number of HPV RNA-negative cases were p16INK4a-positive (17.9%). HPV16 was the major type associated with HNC (60.0%), although cases positive for HPV18, 35 and 56 were also detected. Our data indicate that the proportion and types of mucosal HR-HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world. This may be explained by differences in smoking and/or sexual behaviour compared with North America and northern Europe. Moreover, we show that p16INK4a staining appeared not to be a good surrogate marker of HPV transformation in the Indian HNC cases.
AB - Mucosal high-risk (HR) human papillomaviruses (HPV) cause a subset of head and neck cancers (HNC). The HPV-attributable fraction of HNC varies substantially between countries. Although HNC has a very high incidence in the Indian subcontinent, information on the contribution of HPV infection is limited. Here, we evaluated the HPV-attributable fraction in HNC (N = 364) collected in a central region of India. HNC from three different anatomical subsites were included, namely, oral cavity (n = 252), oropharynx (n = 53) and hypopharynx/larynx (n = 59). In this retrospective study, HPV-driven HNC were defined by presence of both viral DNA and RNA. Overexpression of p16INK4a was also evaluated. HR-HPV DNA was detected in 13.7% of the cases; however, only 2.7% were positive for both HPV DNA and RNA. The highest percentage of HPV DNA/RNA double positivity was found in oropharynx (9.4%), followed by larynx (1.7%) and oral cavity (1.6%) (p = 0.02). More than half of HPV DNA/RNA-positive cases were p16INK4a-negative, while a considerable number of HPV RNA-negative cases were p16INK4a-positive (17.9%). HPV16 was the major type associated with HNC (60.0%), although cases positive for HPV18, 35 and 56 were also detected. Our data indicate that the proportion and types of mucosal HR-HPV associated with HNC in this central Indian region differ from those in other (developed) parts of the world. This may be explained by differences in smoking and/or sexual behaviour compared with North America and northern Europe. Moreover, we show that p16INK4a staining appeared not to be a good surrogate marker of HPV transformation in the Indian HNC cases.
KW - central India
KW - head and neck cancer
KW - HPV
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U2 - 10.1002/ijc.30712
DO - 10.1002/ijc.30712
M3 - Article
C2 - 28369859
AN - SCOPUS:85018477501
VL - 141
SP - 143
EP - 151
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 1
ER -