Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections

N. Principi, S. Esposito, F. Blasi, L. Allegra, R. Longhi, R. M. Grasso, R. Vaccaro, S. Troiani, F. Tancredi, L. Tarallo, L. Gargantini, P. Cazzaniga, L. Titone, A. Cascio, L. Zannino, C. Navone, C. Debbia, L. Nespoli, E. Ossola, F. Schettini & 22 others N. Rigillo, F. Amendola, L. Mappa, G. Bona, B. Ronchi, S. Bernasconi, L. Iughetti, S. Cocuzza, M. Raggi, I. Barberi, G. Lombardo, S. Gitto, T. Sirchia, S. Volpato, A. Voghenzi, G. Caramia, E. Ruffini, F. Cordelli, R. Brutti, S. Santovito, S. Catania, C. Ajassa

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215 Citations (Scopus)

Abstract

In order to evaluate the role of Mycoplasma pneumoniae and Chlamydia pneumoniae, we studied 613 children aged 2-14 years who were hospitalized for community-acquired lower respiratory tract infections (LRTIs). The patients were enrolled in the study by 21 centers in different regions of Italy from May 1998 through April 1999. Paired serum samples were obtained on admission and after 4-6 weeks to assay the titers of M. pneumoniae and C. pneumoniae antibodies. Nasopharyngeal aspirates for the detection of M. pneumoniae and C. pneumoniae were obtained on admission. Acute M. pneumoniae infections in 210 patients (34.3%) and acute C. pneumoniae infections in 87 (14.1%) were diagnosed. Fifteen of the 18 children with M. pneumoniae and/or C. pneumoniae infections whose treatments were considered clinical failures 4-6 weeks after enrollment had not been treated with macrolides. Our study confirms that M. pneumoniae and/or C. pneumoniae plays a significant role in community-acquired LRTIs in children of all ages and that such infections have a more complicated course when not treated with adequate antimicrobial agents.

Original languageEnglish
Pages (from-to)1281-1289
Number of pages9
JournalClinical Infectious Diseases
Volume32
Issue number9
DOIs
Publication statusPublished - May 1 2001

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Chlamydophila pneumoniae
Mycoplasma pneumoniae
Respiratory Tract Infections
Chlamydia Infections
Macrolides
Anti-Infective Agents
Infection
Italy
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. / Principi, N.; Esposito, S.; Blasi, F.; Allegra, L.; Longhi, R.; Grasso, R. M.; Vaccaro, R.; Troiani, S.; Tancredi, F.; Tarallo, L.; Gargantini, L.; Cazzaniga, P.; Titone, L.; Cascio, A.; Zannino, L.; Navone, C.; Debbia, C.; Nespoli, L.; Ossola, E.; Schettini, F.; Rigillo, N.; Amendola, F.; Mappa, L.; Bona, G.; Ronchi, B.; Bernasconi, S.; Iughetti, L.; Cocuzza, S.; Raggi, M.; Barberi, I.; Lombardo, G.; Gitto, S.; Sirchia, T.; Volpato, S.; Voghenzi, A.; Caramia, G.; Ruffini, E.; Cordelli, F.; Brutti, R.; Santovito, S.; Catania, S.; Ajassa, C.

In: Clinical Infectious Diseases, Vol. 32, No. 9, 01.05.2001, p. 1281-1289.

Research output: Contribution to journalArticle

Principi, N, Esposito, S, Blasi, F, Allegra, L, Longhi, R, Grasso, RM, Vaccaro, R, Troiani, S, Tancredi, F, Tarallo, L, Gargantini, L, Cazzaniga, P, Titone, L, Cascio, A, Zannino, L, Navone, C, Debbia, C, Nespoli, L, Ossola, E, Schettini, F, Rigillo, N, Amendola, F, Mappa, L, Bona, G, Ronchi, B, Bernasconi, S, Iughetti, L, Cocuzza, S, Raggi, M, Barberi, I, Lombardo, G, Gitto, S, Sirchia, T, Volpato, S, Voghenzi, A, Caramia, G, Ruffini, E, Cordelli, F, Brutti, R, Santovito, S, Catania, S & Ajassa, C 2001, 'Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections', Clinical Infectious Diseases, vol. 32, no. 9, pp. 1281-1289. https://doi.org/10.1086/319981
Principi, N. ; Esposito, S. ; Blasi, F. ; Allegra, L. ; Longhi, R. ; Grasso, R. M. ; Vaccaro, R. ; Troiani, S. ; Tancredi, F. ; Tarallo, L. ; Gargantini, L. ; Cazzaniga, P. ; Titone, L. ; Cascio, A. ; Zannino, L. ; Navone, C. ; Debbia, C. ; Nespoli, L. ; Ossola, E. ; Schettini, F. ; Rigillo, N. ; Amendola, F. ; Mappa, L. ; Bona, G. ; Ronchi, B. ; Bernasconi, S. ; Iughetti, L. ; Cocuzza, S. ; Raggi, M. ; Barberi, I. ; Lombardo, G. ; Gitto, S. ; Sirchia, T. ; Volpato, S. ; Voghenzi, A. ; Caramia, G. ; Ruffini, E. ; Cordelli, F. ; Brutti, R. ; Santovito, S. ; Catania, S. ; Ajassa, C. / Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections. In: Clinical Infectious Diseases. 2001 ; Vol. 32, No. 9. pp. 1281-1289.
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AU - Principi, N.

AU - Esposito, S.

AU - Blasi, F.

AU - Allegra, L.

AU - Longhi, R.

AU - Grasso, R. M.

AU - Vaccaro, R.

AU - Troiani, S.

AU - Tancredi, F.

AU - Tarallo, L.

AU - Gargantini, L.

AU - Cazzaniga, P.

AU - Titone, L.

AU - Cascio, A.

AU - Zannino, L.

AU - Navone, C.

AU - Debbia, C.

AU - Nespoli, L.

AU - Ossola, E.

AU - Schettini, F.

AU - Rigillo, N.

AU - Amendola, F.

AU - Mappa, L.

AU - Bona, G.

AU - Ronchi, B.

AU - Bernasconi, S.

AU - Iughetti, L.

AU - Cocuzza, S.

AU - Raggi, M.

AU - Barberi, I.

AU - Lombardo, G.

AU - Gitto, S.

AU - Sirchia, T.

AU - Volpato, S.

AU - Voghenzi, A.

AU - Caramia, G.

AU - Ruffini, E.

AU - Cordelli, F.

AU - Brutti, R.

AU - Santovito, S.

AU - Catania, S.

AU - Ajassa, C.

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