Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

Giada Amodio, Joanna Cichy, Patricia Conde, Gianluca Matteoli, Aurélie Moreau, Jordi Ochando, Barbaros H. Oral, Michaela Pekarova, Elizabeth J. Ryan, Johannes Roth, Yahya Sohrabi, Maria Cristina Cuturi, Silvia Gregori

Research output: Contribution to journalReview articlepeer-review

Abstract

Myeloid cells play a pivotal role in regulating innate and adaptive immune responses. In inflammation, autoimmunity, and after transplantation, myeloid cells have contrasting roles: on the one hand they initiate the immune response, promoting activation and expansion of effector T-cells, and on the other, they counter-regulate inflammation, maintain tissue homeostasis, and promote tolerance. The latter activities are mediated by several myeloid cells including polymorphonuclear neutrophils, macrophages, myeloid-derived suppressor cells, and dendritic cells. Since these cells have been associated with immune suppression and tolerance, they will be further referred to as myeloid regulatory cells (MRCs). In recent years, MRCs have emerged as a therapeutic target or have been regarded as a potential cellular therapeutic product for tolerance induction. However, several open questions must be addressed to enable the therapeutic application of MRCs including: how do they function at the site of inflammation, how to best target these cells to modulate their activities, and how to isolate or to generate pure populations for adoptive cell therapies. In this review, we will give an overview of the current knowledge on MRCs in inflammation, autoimmunity, and transplantation. We will discuss current strategies to target MRCs and to exploit their tolerogenic potential as a cell-based therapy.

Original languageEnglish
Pages (from-to)661-672
Number of pages12
JournalCancer Immunology, Immunotherapy
Volume68
Issue number4
DOIs
Publication statusPublished - Apr 2 2019

Keywords

  • Dendritic cells
  • Monocytes/macrophages
  • Mye-EUNITER
  • Myeloid regulatory cells (MRCs)
  • Polymorphonuclear neutrophils
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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