Role of N-terminal pro-brain natriuretic peptide in detecting clinically significant cardiac involvement in systemic sclerosis patients

Cecilia Chighizola, Pier Luigi Meroni, Benjamin E. Schreiber, John G. Coghlan, Christopher P. Denton, Voon H. Ong

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Cardiac involvement is recognised as a poor prognostic factor among systemic sclerosis (SSc) patients, contributing significantly to mortality. We assessed the role of N-TproBNP in SSc-related cardiac involvement in a retrospective cohort of patients. Methods: Serum N-TproBNP levels were measured in 21 SSc patients with clinically significant cardiac involvement and in a control group of 42 SSc patients without any evidence of heart involvement. All patients had normal pulmonary artery systolic pressure and none had serum creatinine above 140 micromol/L. Results: Compared with those without cardiac involvement, N-TproBNP was significantly increased in SSc patients with heart involvement (median 11 and 219 pmol/L respectively, p

Original languageEnglish
JournalClinical and Experimental Rheumatology
Volume30
Issue numberSUPPL.71
Publication statusPublished - May 2012

Keywords

  • Cardiac involvement
  • N-TproBNP
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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