Role of new imaging modalities in pursuit of the vulnerable plaque and the vulnerable patient

Research output: Contribution to journalReview article

Abstract

Numerous biomarkers and imaging modalities were investigated during the past few decades to identify patients harboring plaques at high risk of rupturing and causing catastrophic events. The classical description of a vulnerable plaque included a large lipid core, covered by a thin fibrous cap and evidence of inflammation especially around the hinge points of the plaque. Unfortunately, the search has resulted to a large extent in a failure to accurately identify the site of a future event. In time the search focus switched to the vulnerable patient rather than the individual vulnerable plaques, but the debate continues as to the more appropriate approach to risk assessment. This review discusses the most recent developments in molecular, anatomical and functional imaging directed at identifying a patient at high-risk of coronary artery disease events.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalInternational Journal of Cardiology
Volume250
DOIs
Publication statusPublished - Jan 1 2018

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Coronary Artery Disease
Biomarkers
Inflammation
Lipids

Keywords

  • Journal Article
  • Review

Cite this

Role of new imaging modalities in pursuit of the vulnerable plaque and the vulnerable patient. / Raggi, Paolo; Pontone, Gianluca; Andreini, Daniele.

In: International Journal of Cardiology, Vol. 250, 01.01.2018, p. 278-283.

Research output: Contribution to journalReview article

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