Role of nitric oxide in cell-mediated tumor cytotoxicity

M. Grazia Cifone, Luisa Cironi, M. Antonietta Meccia, Paola Roncaioli, Claudio Festuccia, Gasperina De Nuntiis, Simona D'Aló, Angela Santoni

Research output: Contribution to journalArticlepeer-review


Strong and increasing evidence shows that nitric oxide (NO) contributes to immune function, and in particular to 'non-specific host defense'. The aim of the present review was to focus the current understanding of the role of NO as a biochemical effector of l-arginine-dependent cell-mediated immune responses to neoplastic cells in vitro and in vivo. The cytokine-inducible nitric oxide synthase (NOS) seems to mainly be implicated in the cytotoxic activity of almost all the effector cells involved in tumor cell killing. The cytotoxic actions of NO against tumor cells appear to be related mainly to inhibition of several heme-containing enzymes of the mitochondrial electron transport complex and the citric acid cycle.

Original languageEnglish
Pages (from-to)443-461
Number of pages19
JournalAdvances in Neuroimmunology
Issue number4
Publication statusPublished - 1995


  • cell-mediated tumor cytotoxicity
  • Nitric oxide

ASJC Scopus subject areas

  • Immunology
  • Neuroscience(all)


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