Abstract
The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.
| Original language | English |
|---|---|
| Pages (from-to) | 197-201 |
| Number of pages | 5 |
| Journal | Journal of Clinical Immunology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1984 |
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Keywords
- adherent cells
- Autologous mixed lymphocyte reaction
- lymphocytes
- suppressor cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Role of normal adherent cells in the regulation of the autologous mixed lymphocyte reactions in humans. / Pierri, Ivana; Rogna, Silvia; Pende, Daniela; Viglione, Daniela; Scudeletti, Marco; Barabino, Andrea; Indiveri, Francesco.
In: Journal of Clinical Immunology, Vol. 4, No. 3, 05.1984, p. 197-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of normal adherent cells in the regulation of the autologous mixed lymphocyte reactions in humans
AU - Pierri, Ivana
AU - Rogna, Silvia
AU - Pende, Daniela
AU - Viglione, Daniela
AU - Scudeletti, Marco
AU - Barabino, Andrea
AU - Indiveri, Francesco
PY - 1984/5
Y1 - 1984/5
N2 - The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.
AB - The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.
KW - adherent cells
KW - Autologous mixed lymphocyte reaction
KW - lymphocytes
KW - suppressor cells
UR - http://www.scopus.com/inward/record.url?scp=0021166202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021166202&partnerID=8YFLogxK
U2 - 10.1007/BF00914966
DO - 10.1007/BF00914966
M3 - Article
C2 - 6234323
AN - SCOPUS:0021166202
VL - 4
SP - 197
EP - 201
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 3
ER -