Role of normal adherent cells in the regulation of the autologous mixed lymphocyte reactions in humans

Ivana Pierri, Silvia Rogna, Daniela Pende, Daniela Viglione, Marco Scudeletti, Andrea Barabino, Francesco Indiveri

Research output: Contribution to journalArticle

Abstract

The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalJournal of Clinical Immunology
Volume4
Issue number3
DOIs
Publication statusPublished - May 1984

Keywords

  • adherent cells
  • Autologous mixed lymphocyte reaction
  • lymphocytes
  • suppressor cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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