Abstract
The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.
Original language | English |
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Pages (from-to) | 197-201 |
Number of pages | 5 |
Journal | Journal of Clinical Immunology |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 1984 |
Keywords
- adherent cells
- Autologous mixed lymphocyte reaction
- lymphocytes
- suppressor cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology