Role of nuclear PLC and PI3K signaling in the development of cancer

Irene Faenza, Giulia Ramazzotti, Alberto Bavelloni, Lisa Bregoli, Roberta Flume, Gian Carlo Gaboardi, Lucia Manzoli, Alessandro Matteucci, Alberto M. Martelli, Lucio Cocco

Research output: Contribution to journalArticle

Abstract

The discovery of an autonomous nuclear inositide signal has resulted in a new understanding of how this system could be involved in the control of processes such as cell growth and differentiation as well as neoplastic transformation. The aim of this review is to outline the main achievements of the past few years and their possible clinical applications.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalFuture Lipidology
Volume2
Issue number3
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Cancer
  • Nucleus
  • Phosphatase and tensin homolog deleted on chromosome 10
  • Phosphatidyl inositol 3 kinases
  • Phosphoinositide-specific phospholipases C

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Faenza, I., Ramazzotti, G., Bavelloni, A., Bregoli, L., Flume, R., Gaboardi, G. C., Manzoli, L., Matteucci, A., Martelli, A. M., & Cocco, L. (2007). Role of nuclear PLC and PI3K signaling in the development of cancer. Future Lipidology, 2(3), 303-311. https://doi.org/10.2217/17460875.2.3.303